Mass spectrometry for drug discovery and drug development /
Mass spectrometry for drug discovery and drug development /
edited by Walter A. Korfmacher.
- Hoboken, N.J. : Wiley, 2013.
- 1 online resource (xii, 461 pages, [16] pages of plates)) : illustrations (some color).
- Wiley series on mass spectrometry .
- Wiley-Interscience series on mass spectrometry. .
Includes bibliographical references and index.
1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner -- 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang -- 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia -- 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou -- 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash -- 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky -- 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak -- 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion -- 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendraÿ N. Pramanik -- 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli -- 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer -- 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury -- 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan -- 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily -- 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens.
This book presents a summary of the ways mass spectrometry is used in various stages of drug discovery and development including early support of medicinal chemistry, drug metabolism studies, distribution, degradation, and various development assays. The book includes a balance of basic and advanced information. Specific chapters relate to various stages in the process (e.g., discovery) as well as chapters on topics of current interest (lipidomics and SiRNA) are covered.
9781118516157 111851615X 9781118516126 1118516125 9781283917520 1283917521
10.1002/9781118516157 Wiley InterScience http://www3.interscience.wiley.com
Drugs--Analysis.
Drug development.
Mass spectrometry.
Drug Discovery.
Mass Spectrometry--methods.
Peptides--analysis.
Pharmaceutical Preparations--analysis.
Proteins--analysis.
Drug discovery.
Mass spectrometry--Methods.
Peptides--Analysis.
Pharmaceutical preparations--Analysis.
Proteins--Analysis.
MEDICAL--Drug Guides.
MEDICAL--Nursing--Pharmacology.
MEDICAL--Pharmacology.
MEDICAL--Pharmacy.
Drug development.
Drugs--Analysis.
Mass spectrometry.
Electronic books.
RS189.5.S65 / M37 2013eb
615.1 615.19
QV 744
Includes bibliographical references and index.
1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner -- 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang -- 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia -- 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou -- 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash -- 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky -- 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak -- 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion -- 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendraÿ N. Pramanik -- 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli -- 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer -- 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury -- 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan -- 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily -- 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens.
This book presents a summary of the ways mass spectrometry is used in various stages of drug discovery and development including early support of medicinal chemistry, drug metabolism studies, distribution, degradation, and various development assays. The book includes a balance of basic and advanced information. Specific chapters relate to various stages in the process (e.g., discovery) as well as chapters on topics of current interest (lipidomics and SiRNA) are covered.
9781118516157 111851615X 9781118516126 1118516125 9781283917520 1283917521
10.1002/9781118516157 Wiley InterScience http://www3.interscience.wiley.com
Drugs--Analysis.
Drug development.
Mass spectrometry.
Drug Discovery.
Mass Spectrometry--methods.
Peptides--analysis.
Pharmaceutical Preparations--analysis.
Proteins--analysis.
Drug discovery.
Mass spectrometry--Methods.
Peptides--Analysis.
Pharmaceutical preparations--Analysis.
Proteins--Analysis.
MEDICAL--Drug Guides.
MEDICAL--Nursing--Pharmacology.
MEDICAL--Pharmacology.
MEDICAL--Pharmacy.
Drug development.
Drugs--Analysis.
Mass spectrometry.
Electronic books.
RS189.5.S65 / M37 2013eb
615.1 615.19
QV 744