Cyclic-nucleotide phosphodiesterases in the central nervous system :
Cyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery /
edited by Nicholas J. Brandon, Anthony R. West.
- 1 online resource (xi, 386 pages) : illustrations (some color).
- Wiley series in drug discovery and development .
- Wiley series in drug discovery and development. .
Includes bibliographical references.
Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.
9781118836323 1118836324 9781118836309 1118836308 9781118836538 1118836537 9781118836507 1118836502 047056668X 9780470566688
2013043100
Cyclic nucleotide phosphodiesterases.
Central nervous system--Physiology.
Nucleotides, Cyclic.
3',5'-Cyclic-AMP Phosphodiesterases--metabolism.
3',5'-Cyclic-AMP Phosphodiesterases--therapeutic use.
Central Nervous System--physiology.
Central Nervous System Diseases--drug therapy.
Drug Discovery.
MEDICAL--Physiology.
SCIENCE--Life Sciences--Human Anatomy & Physiology.
Central nervous system.
Cyclic nucleotide phosphodiesterases.
Electronic books.
Electronic books.
QP370
612.8/2
QU 136
Includes bibliographical references.
Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.
9781118836323 1118836324 9781118836309 1118836308 9781118836538 1118836537 9781118836507 1118836502 047056668X 9780470566688
2013043100
Cyclic nucleotide phosphodiesterases.
Central nervous system--Physiology.
Nucleotides, Cyclic.
3',5'-Cyclic-AMP Phosphodiesterases--metabolism.
3',5'-Cyclic-AMP Phosphodiesterases--therapeutic use.
Central Nervous System--physiology.
Central Nervous System Diseases--drug therapy.
Drug Discovery.
MEDICAL--Physiology.
SCIENCE--Life Sciences--Human Anatomy & Physiology.
Central nervous system.
Cyclic nucleotide phosphodiesterases.
Electronic books.
Electronic books.
QP370
612.8/2
QU 136