Epigenetics and regeneration /
Palacios, Daniela,
Epigenetics and regeneration / Daniela Palacios. - First edition. - 1 online resource - Translational epigenetics series ; v. 11 . - Translational epigenetics series ; v. 11. .
Includes index.
Includes bibliographical references and index.
Front Cover; Epigenetics and Regeneration; Copyright; Contents; Contributors; Chapter 1: Epigenetics and Regeneration: An Overview; 1.1. Introduction; 1.2. Epigenetic Regulation of Gene Expression and Cell Fate; 1.3. Development, Reprogramming, and Tissue Regeneration: From the Zygote to Emerging Sources of Multipotent Cells for Re ... ; 1.4. The Epigenetics of Tissue Development, Homeostasis, and Regeneration; 1.5. Epigenetics and Environment: How Age, Environmental Cues, and Epigenetic Drugs Influence The Capability of Stem Cell ... 1.6. Conclusions: Is There a Place for Epigenetics in Regenerative Medicine?Acknowledgments; List of Abbreviations; References; Section I: Epigenetics: Molecular Players and Mechanisms; Chapter 2: Dynamics and Mechanisms of DNA Methylation Reprogramming; 2.1. Introduction; 2.2. DNA Methylation Machinery; 2.3. DNA Demethylation; 2.4. DNA Methylation in Early Development; 2.5. How Necessary is DNA Methylation Reprogramming for Early Development?; 2.6. DNA Methylation Trajectories During Reprogramming of Somatic Cells; 2.7. 6-Methyldeoxyadenosine in Mammalian DNA?; 2.8. Future Perspectives AcknowledgmentsReferences; Chapter 3: Histone Modifications; 3.1. Epigenetics and Chromatin Dynamics; 3.2. Histone Modifications; 3.2.1. Histone Lysine Acetylation; 3.2.2. Histone Lysine Methylation; 3.2.3. Histone Lysine Methylation in Transcription; 3.2.3.1. Gene silencing by histone H3 lysine 9 and lysine 27 methylation; 3.2.3.2. Gene activation by H3 lysine 4 and H3 lysine 36 methylation; 3.2.4. Histone Arginine Methylation; 3.2.5. Histone Phosphorylation; 3.2.6. Histone Ubiquitination; 3.2.7. Histone Sumoylation; 3.2.8. Histone Glycosylation; 3.2.9. Histone Poly-ADP Ribosylation 3.3. The Histone Code3.3.1. Bivalent Domains, Promoters, and Enhancers; 3.3.2. Histone Modifications and Nuclear Organization; 3.4. Histone Modifications in Cell Fate Changes and Cell Differentiation; 3.4.1. Histone Modifications as Regulators of Neuronal Development and Function; 3.4.2. Histone Mutations in Disease: The Example of Histone Gene Mutations in Brain Tumors; 3.4.3. Histone Modifications in Skeletal Muscle Differentiation and Regeneration; 3.5. Conclusions and Perspectives; List of Abbreviations; References Chapter 4: Noncoding RNAs as Regulators of Gene Expression in Pluripotency and Differentiation4.1. Introduction; 4.1.1. Classification and Mechanisms of Action; 4.2. The Role of miRNAs in Pluripotency; 4.2.1. miRNAs as Regulators of the Cell Cycle and Apoptosis of Embryonic Stem Cells (ESCs); 4.2.2. miRNAs Regulating the Maintenance of Self-Renewal and Pluripotency of ESCs; 4.2.3. miRNAs in Somatic Cell Reprogramming Towards iPSCs; 4.3. miRNAs as Regulators of Cell Fate and Cell Differentiation; 4.3.1. miRNAs and Regulation of Muscle Differentiation
9780128148808 0128148802 0128148799 9780128148792
Epigenetics.
Regeneration (Biology)
Epigenomics.
SCIENCE--Life Sciences--Biochemistry.
Epigenetics.
Regeneration (Biology)
QH450 / .P35 2019
572.865
QU 460
Epigenetics and regeneration / Daniela Palacios. - First edition. - 1 online resource - Translational epigenetics series ; v. 11 . - Translational epigenetics series ; v. 11. .
Includes index.
Includes bibliographical references and index.
Front Cover; Epigenetics and Regeneration; Copyright; Contents; Contributors; Chapter 1: Epigenetics and Regeneration: An Overview; 1.1. Introduction; 1.2. Epigenetic Regulation of Gene Expression and Cell Fate; 1.3. Development, Reprogramming, and Tissue Regeneration: From the Zygote to Emerging Sources of Multipotent Cells for Re ... ; 1.4. The Epigenetics of Tissue Development, Homeostasis, and Regeneration; 1.5. Epigenetics and Environment: How Age, Environmental Cues, and Epigenetic Drugs Influence The Capability of Stem Cell ... 1.6. Conclusions: Is There a Place for Epigenetics in Regenerative Medicine?Acknowledgments; List of Abbreviations; References; Section I: Epigenetics: Molecular Players and Mechanisms; Chapter 2: Dynamics and Mechanisms of DNA Methylation Reprogramming; 2.1. Introduction; 2.2. DNA Methylation Machinery; 2.3. DNA Demethylation; 2.4. DNA Methylation in Early Development; 2.5. How Necessary is DNA Methylation Reprogramming for Early Development?; 2.6. DNA Methylation Trajectories During Reprogramming of Somatic Cells; 2.7. 6-Methyldeoxyadenosine in Mammalian DNA?; 2.8. Future Perspectives AcknowledgmentsReferences; Chapter 3: Histone Modifications; 3.1. Epigenetics and Chromatin Dynamics; 3.2. Histone Modifications; 3.2.1. Histone Lysine Acetylation; 3.2.2. Histone Lysine Methylation; 3.2.3. Histone Lysine Methylation in Transcription; 3.2.3.1. Gene silencing by histone H3 lysine 9 and lysine 27 methylation; 3.2.3.2. Gene activation by H3 lysine 4 and H3 lysine 36 methylation; 3.2.4. Histone Arginine Methylation; 3.2.5. Histone Phosphorylation; 3.2.6. Histone Ubiquitination; 3.2.7. Histone Sumoylation; 3.2.8. Histone Glycosylation; 3.2.9. Histone Poly-ADP Ribosylation 3.3. The Histone Code3.3.1. Bivalent Domains, Promoters, and Enhancers; 3.3.2. Histone Modifications and Nuclear Organization; 3.4. Histone Modifications in Cell Fate Changes and Cell Differentiation; 3.4.1. Histone Modifications as Regulators of Neuronal Development and Function; 3.4.2. Histone Mutations in Disease: The Example of Histone Gene Mutations in Brain Tumors; 3.4.3. Histone Modifications in Skeletal Muscle Differentiation and Regeneration; 3.5. Conclusions and Perspectives; List of Abbreviations; References Chapter 4: Noncoding RNAs as Regulators of Gene Expression in Pluripotency and Differentiation4.1. Introduction; 4.1.1. Classification and Mechanisms of Action; 4.2. The Role of miRNAs in Pluripotency; 4.2.1. miRNAs as Regulators of the Cell Cycle and Apoptosis of Embryonic Stem Cells (ESCs); 4.2.2. miRNAs Regulating the Maintenance of Self-Renewal and Pluripotency of ESCs; 4.2.3. miRNAs in Somatic Cell Reprogramming Towards iPSCs; 4.3. miRNAs as Regulators of Cell Fate and Cell Differentiation; 4.3.1. miRNAs and Regulation of Muscle Differentiation
9780128148808 0128148802 0128148799 9780128148792
Epigenetics.
Regeneration (Biology)
Epigenomics.
SCIENCE--Life Sciences--Biochemistry.
Epigenetics.
Regeneration (Biology)
QH450 / .P35 2019
572.865
QU 460