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Natural Products and Cancer Drug Discovery (Record no. 44154)

MARC details
000 -LEADER
fixed length control field 03893nam a22004937a 4500
001 - CONTROL NUMBER
control field sulb-eb0022062
003 - CONTROL NUMBER IDENTIFIER
control field BD-SySUS
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20160413122221.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 121116s2013 xxu| s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781461446545
-- 978-1-4614-4654-5
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1007/978-1-4614-4654-5
Source of number or code doi
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC261-271
072 #7 - SUBJECT CATEGORY CODE
Subject category code MJCL
Source bicssc
Subject category code MED062000
Source bisacsh
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 614.5999
Edition number 23
245 10 - TITLE STATEMENT
Title Natural Products and Cancer Drug Discovery
Medium [electronic resource] /
Statement of responsibility, etc. edited by Frank E. Koehn.
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture New York, NY :
Name of producer, publisher, distributor, manufacturer Springer New York :
-- Imprint: Springer,
Date of production, publication, distribution, manufacture, or copyright notice 2013.
300 ## - PHYSICAL DESCRIPTION
Extent XII, 244 p.
Other physical details online resource.
336 ## - CONTENT TYPE
Content type term text
Content type code txt
Source rdacontent
337 ## - MEDIA TYPE
Media type term computer
Media type code c
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term online resource
Carrier type code cr
Source rdacarrier
347 ## - DIGITAL FILE CHARACTERISTICS
File type text file
Encoding format PDF
Source rda
490 1# - SERIES STATEMENT
Series statement Cancer Drug Discovery and Development
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Preface.-  The Impact of Natural Products upon Cancer Chemotherapy -- Identification and development of vascular disrupting agents: Natural products that interfere with tumor growth -- Discodermolide: Past, Present and Future -- HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents -- Natural Product Cytotoxins As Payloads For Antibody Drug Conjugates -- Natural Product Scaffolds in Cancer Therapy -- The Role of Genetic Engineering in Natural Product-based Anticancer Drug Discovery -- Accessing Anti-Cancer Natural Products by Plant Cell Culture -- Natural Products as Tools for Discovering New Cancer Targets -- Index.
520 ## - SUMMARY, ETC.
Summary, etc. Natural products- compounds derived from plants, microbes and marine organisms, have been an unsurpassed source of cancer drugs in the modern era of drug discovery.  The historical record is strong, but what is the current impact of natural  products in the discovery and development of cancer drugs, and importantly what are the prospects for natural products to be a valuable source of  future agents?  This volume attempts to address this question through a series of chapters authored by leading researchers in the field which effectively provide an in-depth view of several high impact areas of natural products cancer research. The volume begins with a focused analysis and rationale for the clinical success  of current natural product anti-cancer drugs. The following chapters then describe new natural product based drugs in three rapidly evolving target classes and modalities- agents which target tumor vasculature, inhibitors of histone deacetylase and other histone modifying enzymes, and  antibody drug conjugates.  Subsequent chapters examine the central role of natural product chemical scaffolds in the genesis of new anti-cancer therapeutics- first via the powerful application of chemical synthesis, and then through the  rapidly emerging fields of biosynthetic engineering and plant cell culture.  The volume concludes with an assessment of the critical role that natural products continue to play in the search for new cancer drug targets.  As the reader makes his or her way through the volume it may become clear that there is strong evidence that natural products will continue to exert a profound positive impact on cancer drug discovery.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Cancer research.
Topical term or geographic name as entry element Pharmacology.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Biomedicine.
Topical term or geographic name as entry element Cancer Research.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Pharmacology/Toxicology.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Koehn, Frank E.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Relationship information Printed edition:
International Standard Book Number 9781461446538
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title Cancer Drug Discovery and Development
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1007/978-1-4614-4654-5">http://dx.doi.org/10.1007/978-1-4614-4654-5</a>
912 ## -
-- ZDB-2-SME
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Koha item type

No items available.