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RNA and Cancer (Record no. 46068)

MARC details
000 -LEADER
fixed length control field 03944nam a22005177a 4500
001 - CONTROL NUMBER
control field sulb-eb0023976
003 - CONTROL NUMBER IDENTIFIER
control field BD-SySUS
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20160413122418.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 130321s2013 gw | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783642316593
-- 978-3-642-31659-3
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1007/978-3-642-31659-3
Source of number or code doi
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC254-282
072 #7 - SUBJECT CATEGORY CODE
Subject category code MJCL
Source bicssc
Subject category code MED062000
Source bisacsh
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 616.994
Edition number 23
245 10 - TITLE STATEMENT
Title RNA and Cancer
Medium [electronic resource] /
Statement of responsibility, etc. edited by Jane Y. Wu.
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Berlin, Heidelberg :
Name of producer, publisher, distributor, manufacturer Springer Berlin Heidelberg :
-- Imprint: Springer,
Date of production, publication, distribution, manufacture, or copyright notice 2013.
300 ## - PHYSICAL DESCRIPTION
Extent XIII, 245 p.
Other physical details online resource.
336 ## - CONTENT TYPE
Content type term text
Content type code txt
Source rdacontent
337 ## - MEDIA TYPE
Media type term computer
Media type code c
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term online resource
Carrier type code cr
Source rdacarrier
347 ## - DIGITAL FILE CHARACTERISTICS
File type text file
Encoding format PDF
Source rda
490 1# - SERIES STATEMENT
Series statement Cancer Treatment and Research,
International Standard Serial Number 0927-3042 ;
Volume/sequential designation 158
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Coupling between transcription and alternative splicing -- Detection of alternatively spliced or processed RNAs in cancer using oligonucleotide microarray -- Cancer-associated perturbations in alternative pre-messenger RNA splicing -- Alternative splicing of tumor suppressors and oncogenes -- MicroRNAs in cancer.-The perinucleolar compartment: RNA metabolism and cancer -- Regulation of ARE-mRNA stability by cellular signaling: implications for human cancer -- Alternative pre-mRNA splicing, cell death and cancer -- Oligonucleotide therapeutics in cancer -- Clinical perspective on chemo-resistance and the role of RNA processing.
520 ## - SUMMARY, ETC.
Summary, etc. In the last decade, it has become increasingly clear that RNA is not simply a messenger molecule directing protein synthesis. Rather, it has multiple, versatile functional roles in cells, especially in mammalian gene regulation, and thereby influences almost every aspect of cellular life. This book reviews recent progress in selected areas of RNA processing in which information of particular relevance to cancer development and therapy has been obtained. It opens by examining the coupling between transcription and splicing. Three subsequent chapters describe in detail cancer-associated aberrant RNAs, new methodology for their detection, and the functional impact on expression of important genes, including oncogenes and tumor suppressor genes. Further topics include the role of microRNAs in cancer and the possible involvement of the perinucleolar compartment. The implications for cancer of regulation of mRNA stability by cellular signaling are discussed, and the importance of splicing defects in the regulation of cell death genes is examined. The potential for the development of oligonucleotide therapeutics is then reviewed before the final chapter considers clinical perspectives on the study of RNA defects in cancer. All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers, leading to improved cancer diagnosis and treatment.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicine.
Topical term or geographic name as entry element Cancer research.
Topical term or geographic name as entry element Human genetics.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Medical biochemistry.
Topical term or geographic name as entry element Medicine & Public Health.
Topical term or geographic name as entry element Oncology.
Topical term or geographic name as entry element Cancer Research.
Topical term or geographic name as entry element Human Genetics.
Topical term or geographic name as entry element Medical Biochemistry.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Wu, Jane Y.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Relationship information Printed edition:
International Standard Book Number 9783642316586
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title Cancer Treatment and Research,
International Standard Serial Number 0927-3042 ;
Volume number/sequential designation 158
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1007/978-3-642-31659-3">http://dx.doi.org/10.1007/978-3-642-31659-3</a>
912 ## -
-- ZDB-2-SME
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Koha item type

No items available.