Gene discovery for disease models / (Record no. 62461)
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| 001 - CONTROL NUMBER | |
| control field | sulb-eb0030809 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | BD-SySUS |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20170713221237.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cn||||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 100706s2011 njuaf ob 001 0 eng d |
| 010 ## - LIBRARY OF CONGRESS CONTROL NUMBER | |
| Canceled/invalid LC control number | 2010028355 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | E7B |
| Language of cataloging | eng |
| Description conventions | pn |
| Transcribing agency | E7B |
| Modifying agency | CDX |
| -- | OCLCQ |
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| -- | 816640780 |
| -- | 860516726 |
| -- | 961562614 |
| -- | 962626156 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780470933947 |
| Qualifying information | (electronic bk.) |
| International Standard Book Number | 0470933941 |
| Qualifying information | (electronic bk.) |
| International Standard Book Number | 9780470933930 |
| Qualifying information | (electronic bk.) |
| International Standard Book Number | 0470933933 |
| Qualifying information | (electronic bk.) |
| International Standard Book Number | 128298974X |
| International Standard Book Number | 9781282989740 |
| Canceled/invalid ISBN | 9780470499467 |
| Qualifying information | (cloth) |
| 029 1# - OTHER SYSTEM CONTROL NUMBER (OCLC) | |
| OCLC library identifier | AU@ |
| System control number | 000049904240 |
| OCLC library identifier | DEBBG |
| System control number | BV040495883 |
| OCLC library identifier | DKDLA |
| System control number | 820120-katalog:000557265 |
| OCLC library identifier | HEBIS |
| System control number | 299817601 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)708563222 |
| Canceled/invalid control number | (OCoLC)778206046 |
| -- | (OCoLC)779616846 |
| -- | (OCoLC)816640780 |
| -- | (OCoLC)860516726 |
| -- | (OCoLC)961562614 |
| -- | (OCoLC)962626156 |
| 037 ## - SOURCE OF ACQUISITION | |
| Stock number | 10.1002/9780470933947 |
| Source of stock number/acquisition | Wiley InterScience |
| Note | http://www3.interscience.wiley.com |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RB155 |
| Item number | .G3584 2011eb |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | HEA |
| Subject category code subdivision | 039060 |
| Source | bisacsh |
| Subject category code | MED |
| Subject category code subdivision | 107000 |
| Source | bisacsh |
| Subject category code | TCB |
| Source | bicssc |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616/.042 |
| Edition number | 22 |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | MAIN |
| 245 00 - TITLE STATEMENT | |
| Title | Gene discovery for disease models / |
| Statement of responsibility, etc. | edited by Weikuan Gu. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | Hoboken, N.J. : |
| Name of publisher, distributor, etc. | Wiley, |
| Date of publication, distribution, etc. | ©2011. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (xiii, 537 pages, [15] pages of plates) : |
| Other physical details | color illustrations |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS | |
| File type | data file |
| Source | rda |
| 380 ## - FORM OF WORK | |
| Form of work | Bibliography |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references and index. |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Introduction : gene discovery-from positional cloning to genomic cloning -- High throughput gene expression analysis and the identification of expression QTLs -- DNA methylation in the pathogenesis of autoimmunity -- Ccell-based analysis with microfluidic chip -- Missing dimension : protein turnover rate measurement in gene discovery -- Bioinformatics tools for the prediction of gene function -- Determination of genomic locations of targeted genetic loci -- Mutation discovery using high throughput mutation screening technology -- Candidate screening through gene expression profile -- Candidate screening through high-density SNP array -- Gene discovery through direct genome sequencing -- Candidate screening through bioinformatics tools -- Using an integrative strategy to identify mutations -- Determination of the function of a mutant in a gene -- Confirmation of a mutation by multiple molecular approaches -- Confirmation of a mutation by microRNA -- Confirmation of function of a gene by translational approaches -- Confirmation of single nucleotide mutations -- Initial identification and confirmation of a QTL gene -- Gene discovery of crop diseases in the post genome era -- Impact of whole genome genetic element analysis on gene discovery of disease models -- Impact of whole genome protein analysis on gene discovery of disease models. |
| 588 0# - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Print version record. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This book provides readers with new paradigms on the mutation discovery in the postgenome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that âThe availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decadesold mouse mutants will be understood precisely at the DNA level in the near future.â? The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when genome sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have not yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, genome resources, bioinformatics tools, and high throughput technologies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of genomic cloning and protocols. This book describes new concepts of gene discovery in the postgenome era and the use of streamlined protocols to identify genes of interest. This book helps identify not only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL). |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medical genetics. |
| Topical term or geographic name as entry element | Mutation (Biology) |
| Topical term or geographic name as entry element | Genomics. |
| Topical term or geographic name as entry element | Genetic disorders. |
| Topical term or geographic name as entry element | HEALTH & FITNESS |
| General subdivision | Diseases |
| -- | Genetic. |
| Source of heading or term | bisacsh |
| Topical term or geographic name as entry element | MEDICAL |
| General subdivision | Genetics. |
| Source of heading or term | bisacsh |
| Topical term or geographic name as entry element | Genetic disorders. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst00940009 |
| Topical term or geographic name as entry element | Genomics. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst00940228 |
| Topical term or geographic name as entry element | Medical genetics. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst01014133 |
| Topical term or geographic name as entry element | Mutation (Biology) |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst01031152 |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gu, Weikuan. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Title | Gene discovery for disease models. |
| Place, publisher, and date of publication | Hoboken, N.J. : Wiley, ©2011 |
| Record control number | (DLC) 2010028355 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://onlinelibrary.wiley.com/book/10.1002/9780470933947">http://onlinelibrary.wiley.com/book/10.1002/9780470933947</a> |
| Public note | Wiley Online Library [Free Download only for SUST IP] |
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