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Medicinal chemistry approaches to personalized medicine / (Record no. 64626)

MARC details
000 -LEADER
fixed length control field 05722cam a2200805Ia 4500
001 - CONTROL NUMBER
control field sulb-eb0032974
003 - CONTROL NUMBER IDENTIFIER
control field BD-SySUS
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20170713221350.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS
fixed length control field m o d
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr cnu---unuuu
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 131206s2014 gw ob 001 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency IDEBK
Language of cataloging eng
Description conventions pn
Transcribing agency IDEBK
Modifying agency EBLCP
-- DG1
-- N$T
-- YDXCP
-- OCLCF
-- OCLCQ
-- DEBSZ
-- COO
-- DEBBG
-- OCLCQ
-- CDX
-- BD-SySUS
019 ## -
-- 870511683
-- 961643563
-- 962637366
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783527677283
Qualifying information (electronic bk.)
International Standard Book Number 3527677283
Qualifying information (electronic bk.)
International Standard Book Number 9783527677252
Qualifying information (electronic bk.)
International Standard Book Number 3527677259
Qualifying information (electronic bk.)
International Standard Book Number 1306168902
Qualifying information (electronic bk.)
International Standard Book Number 9781306168908
Qualifying information (electronic bk.)
International Standard Book Number 9783527333943
International Standard Book Number 3527333940
International Standard Book Number 9783527677269
Qualifying information (Mobi)
International Standard Book Number 3527677267
Qualifying information (Mobi)
International Standard Book Number 9783527677276
Qualifying information (ePub)
International Standard Book Number 3527677275
Qualifying information (ePub)
029 1# - OTHER SYSTEM CONTROL NUMBER (OCLC)
OCLC library identifier DEBBG
System control number BV043396386
OCLC library identifier DEBSZ
System control number 43157054X
OCLC library identifier NZ1
System control number 15495746
OCLC library identifier NZ1
System control number 15905579
035 ## - SYSTEM CONTROL NUMBER
System control number (OCoLC)864744144
Canceled/invalid control number (OCoLC)870511683
-- (OCoLC)961643563
-- (OCoLC)962637366
037 ## - SOURCE OF ACQUISITION
Stock number 548141
Source of stock number/acquisition MIL
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RS403
Classification number RM111
Item number .L384 2013
060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER
Classification number QV 744
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED
Subject category code subdivision 071000
Source bisacsh
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 615.1/9
Edition number 23
049 ## - LOCAL HOLDINGS (OCLC)
Holding library MAIN
245 00 - TITLE STATEMENT
Title Medicinal chemistry approaches to personalized medicine /
Statement of responsibility, etc. edited by Karen Lackey and Bruce D. Roth.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc. Weinheim :
Name of publisher, distributor, etc. Wiley-VCH,
Date of publication, distribution, etc. 2014.
300 ## - PHYSICAL DESCRIPTION
Extent 1 online resource.
336 ## - CONTENT TYPE
Content type term text
Content type code txt
Source rdacontent
337 ## - MEDIA TYPE
Media type term computer
Media type code c
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term online resource
Carrier type code cr
Source rdacarrier
490 1# - SERIES STATEMENT
Series statement Medicinal chemistry ;
Volume/sequential designation Volume 59
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc Includes bibliographical references and index.
588 0# - SOURCE OF DESCRIPTION NOTE
Source of description note Print version record.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Methods and Principles in Medicinal Chemistry; Title Page; Copyright; List of Contributors; Foreword; Preface; A Personal Foreword; Acronyms; Chapter 1: Medicinal Chemistry Approaches to Creating Targeted Medicines; 1.1 Introduction; 1.2 Role of Medicinal Chemistry in Drug Discovery; 1.3 Evolution of Molecular Design for Subsets of Patients; 1.4 Combinations for Effective Therapies; 1.5 Biomarkers in Targeting Patients; 1.6 Emerging Field of Epigenetics; 1.7 Systems Chemical Biology; 1.8 Theranostics and Designing Drug Delivery Systems
Formatted contents note 1.9 Rapid Progress in Further Personalizing Medicine ExpectedReferences; Chapter 2: Discovery of Predictive Biomarkers for Anticancer Drugs; 2.1 Introduction; 2.2 "Oncogene Addiction" as a Paradigm for Clinical Implementation of Predictive Biomarkers; 2.3 Cancer Cell Lines as a Model System for Discovery of Predictive Biomarkers; 2.4 Modeling Drug Resistance to Discover Predictive Biomarkers; 2.5 Discovery of Predictive Biomarkers in the Context of Treatment Combinations; 2.6 Discovery of Predictive Biomarkers for Antiangiogenic Agents; 2.7 Gene Expression Signatures as Predictive Biomarkers
Formatted contents note 2.8 Current Challenges in Discovering Predictive Biomarkers2.9 Future Perspective; References; Chapter 3: Crizotinib; 3.1 Introduction; 3.2 Discovery of Crizotinib ( PF -02341066) [40]; 3.3 Kinase Selectivity of Crizotinib; 3.4 Pharmacology of Crizotinib [45,46]; 3.5 Human Clinical Efficacies of Crizotinib; 3.6 Summary; References; Chapter 4: Discovery and Development of Vemurafenib: First-in-Class Inhibitor of Mutant BRAF for the Treatment of Cancer; 4.1 Background; 4.2 Discovery and Development of Vemurafenib (PLX4032); 4.3 Pharmacology; 4.4 Clinical Efficacy and Safety
Formatted contents note 4.5 Companion Diagnostic (cobas 4800) Development4.6 Synthesis; 4.7 Summary; References; Chapter 5: Targeting Basal-Cell Carcinoma: Discovery and Development of Vismodegib ( GDC -0449), a First-in-Class Inhibitor of the Hedgehog Pathway; 5.1 Introduction; 5.2 Hedgehog and Basal-Cell Carcinoma; 5.3 Cyclopamine as an SMO Antagonist; 5.4 Small-Molecule Inhibitors of SMO; 5.5 Preclinical Characterization of Vismodegib; 5.6 Vismodegib Clinical Experience in Phase I; References; Chapter 6: G-Quadruplexes as Therapeutic Targets in Cancer; 6.1 Introduction; 6.2 Quadruplex Fundamentals
Formatted contents note 6.3 Genomic Quadruplexes6.4 Quadruplexes in Human Telomeres; 6.5 Quadruplexes as Anticancer Targets -- Evidence from In Vivo Studies; 6.6 Native Quadruplex Structures; 6.7 Quadruplex-Small-Molecule Structures; 6.8 Developing Superior Quadruplex-Binding Ligands; 6.9 Conclusions; References; Chapter 7: Identifying Actionable Targets in Cancer Patients; 7.1 Introduction and Background; 7.2 Overview of Genomic Sequencing and Its Impact on the Identification of Actionable Mutations; 7.3 Actionable Targets by Clinical Molecular Profiling: the OICR / PMH Experience
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Pharmaceutical chemistry.
Topical term or geographic name as entry element MEDICAL
General subdivision Pharmacology.
Source of heading or term bisacsh
Topical term or geographic name as entry element Pharmaceutical chemistry.
Source of heading or term fast
Authority record control number (OCoLC)fst01060115
655 #4 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
Genre/form data or focus term Electronic books.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lackey, Karen.
Personal name Roth, Bruce D.
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Relationship information Print version:
Title Medicinal chemistry approaches to personalized medicine.
Place, publisher, and date of publication Weinheim : Wiley-VCH, 2014
International Standard Book Number 9783527677252
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title Medicinal chemistry ;
Volume number/sequential designation Volume 59.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://onlinelibrary.wiley.com/book/10.1002/9783527677252">http://onlinelibrary.wiley.com/book/10.1002/9783527677252</a>
Public note Wiley Online Library [Free Download only for SUST IP]
938 ## -
-- EBL - Ebook Library
-- EBLB
-- EBL1569033
-- EBSCOhost
-- EBSC
-- 668292
-- Ingram Digital eBook Collection
-- IDEB
-- cis26870791
-- YBP Library Services
-- YANK
-- 10706499
-- YBP Library Services
-- YANK
-- 11387981
-- YBP Library Services
-- YANK
-- 12679603
-- Coutts Information Services
-- COUT
-- 26870791
994 ## -
-- 92
-- DG1

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