Medicinal chemistry approaches to personalized medicine / (Record no. 64626)
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000 -LEADER | |
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001 - CONTROL NUMBER | |
control field | sulb-eb0032974 |
003 - CONTROL NUMBER IDENTIFIER | |
control field | BD-SySUS |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20170713221350.0 |
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
fixed length control field | m o d |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
fixed length control field | cr cnu---unuuu |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 131206s2014 gw ob 001 0 eng d |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | IDEBK |
Language of cataloging | eng |
Description conventions | pn |
Transcribing agency | IDEBK |
Modifying agency | EBLCP |
-- | DG1 |
-- | N$T |
-- | YDXCP |
-- | OCLCF |
-- | OCLCQ |
-- | DEBSZ |
-- | COO |
-- | DEBBG |
-- | OCLCQ |
-- | CDX |
-- | BD-SySUS |
019 ## - | |
-- | 870511683 |
-- | 961643563 |
-- | 962637366 |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
International Standard Book Number | 9783527677283 |
Qualifying information | (electronic bk.) |
International Standard Book Number | 3527677283 |
Qualifying information | (electronic bk.) |
International Standard Book Number | 9783527677252 |
Qualifying information | (electronic bk.) |
International Standard Book Number | 3527677259 |
Qualifying information | (electronic bk.) |
International Standard Book Number | 1306168902 |
Qualifying information | (electronic bk.) |
International Standard Book Number | 9781306168908 |
Qualifying information | (electronic bk.) |
International Standard Book Number | 9783527333943 |
International Standard Book Number | 3527333940 |
International Standard Book Number | 9783527677269 |
Qualifying information | (Mobi) |
International Standard Book Number | 3527677267 |
Qualifying information | (Mobi) |
International Standard Book Number | 9783527677276 |
Qualifying information | (ePub) |
International Standard Book Number | 3527677275 |
Qualifying information | (ePub) |
029 1# - OTHER SYSTEM CONTROL NUMBER (OCLC) | |
OCLC library identifier | DEBBG |
System control number | BV043396386 |
OCLC library identifier | DEBSZ |
System control number | 43157054X |
OCLC library identifier | NZ1 |
System control number | 15495746 |
OCLC library identifier | NZ1 |
System control number | 15905579 |
035 ## - SYSTEM CONTROL NUMBER | |
System control number | (OCoLC)864744144 |
Canceled/invalid control number | (OCoLC)870511683 |
-- | (OCoLC)961643563 |
-- | (OCoLC)962637366 |
037 ## - SOURCE OF ACQUISITION | |
Stock number | 548141 |
Source of stock number/acquisition | MIL |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
Classification number | RS403 |
Classification number | RM111 |
Item number | .L384 2013 |
060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
Classification number | QV 744 |
072 #7 - SUBJECT CATEGORY CODE | |
Subject category code | MED |
Subject category code subdivision | 071000 |
Source | bisacsh |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
Classification number | 615.1/9 |
Edition number | 23 |
049 ## - LOCAL HOLDINGS (OCLC) | |
Holding library | MAIN |
245 00 - TITLE STATEMENT | |
Title | Medicinal chemistry approaches to personalized medicine / |
Statement of responsibility, etc. | edited by Karen Lackey and Bruce D. Roth. |
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
Place of publication, distribution, etc. | Weinheim : |
Name of publisher, distributor, etc. | Wiley-VCH, |
Date of publication, distribution, etc. | 2014. |
300 ## - PHYSICAL DESCRIPTION | |
Extent | 1 online resource. |
336 ## - CONTENT TYPE | |
Content type term | text |
Content type code | txt |
Source | rdacontent |
337 ## - MEDIA TYPE | |
Media type term | computer |
Media type code | c |
Source | rdamedia |
338 ## - CARRIER TYPE | |
Carrier type term | online resource |
Carrier type code | cr |
Source | rdacarrier |
490 1# - SERIES STATEMENT | |
Series statement | Medicinal chemistry ; |
Volume/sequential designation | Volume 59 |
504 ## - BIBLIOGRAPHY, ETC. NOTE | |
Bibliography, etc | Includes bibliographical references and index. |
588 0# - SOURCE OF DESCRIPTION NOTE | |
Source of description note | Print version record. |
505 0# - FORMATTED CONTENTS NOTE | |
Formatted contents note | Methods and Principles in Medicinal Chemistry; Title Page; Copyright; List of Contributors; Foreword; Preface; A Personal Foreword; Acronyms; Chapter 1: Medicinal Chemistry Approaches to Creating Targeted Medicines; 1.1 Introduction; 1.2 Role of Medicinal Chemistry in Drug Discovery; 1.3 Evolution of Molecular Design for Subsets of Patients; 1.4 Combinations for Effective Therapies; 1.5 Biomarkers in Targeting Patients; 1.6 Emerging Field of Epigenetics; 1.7 Systems Chemical Biology; 1.8 Theranostics and Designing Drug Delivery Systems |
Formatted contents note | 1.9 Rapid Progress in Further Personalizing Medicine ExpectedReferences; Chapter 2: Discovery of Predictive Biomarkers for Anticancer Drugs; 2.1 Introduction; 2.2 "Oncogene Addiction" as a Paradigm for Clinical Implementation of Predictive Biomarkers; 2.3 Cancer Cell Lines as a Model System for Discovery of Predictive Biomarkers; 2.4 Modeling Drug Resistance to Discover Predictive Biomarkers; 2.5 Discovery of Predictive Biomarkers in the Context of Treatment Combinations; 2.6 Discovery of Predictive Biomarkers for Antiangiogenic Agents; 2.7 Gene Expression Signatures as Predictive Biomarkers |
Formatted contents note | 2.8 Current Challenges in Discovering Predictive Biomarkers2.9 Future Perspective; References; Chapter 3: Crizotinib; 3.1 Introduction; 3.2 Discovery of Crizotinib ( PF -02341066) [40]; 3.3 Kinase Selectivity of Crizotinib; 3.4 Pharmacology of Crizotinib [45,46]; 3.5 Human Clinical Efficacies of Crizotinib; 3.6 Summary; References; Chapter 4: Discovery and Development of Vemurafenib: First-in-Class Inhibitor of Mutant BRAF for the Treatment of Cancer; 4.1 Background; 4.2 Discovery and Development of Vemurafenib (PLX4032); 4.3 Pharmacology; 4.4 Clinical Efficacy and Safety |
Formatted contents note | 4.5 Companion Diagnostic (cobas 4800) Development4.6 Synthesis; 4.7 Summary; References; Chapter 5: Targeting Basal-Cell Carcinoma: Discovery and Development of Vismodegib ( GDC -0449), a First-in-Class Inhibitor of the Hedgehog Pathway; 5.1 Introduction; 5.2 Hedgehog and Basal-Cell Carcinoma; 5.3 Cyclopamine as an SMO Antagonist; 5.4 Small-Molecule Inhibitors of SMO; 5.5 Preclinical Characterization of Vismodegib; 5.6 Vismodegib Clinical Experience in Phase I; References; Chapter 6: G-Quadruplexes as Therapeutic Targets in Cancer; 6.1 Introduction; 6.2 Quadruplex Fundamentals |
Formatted contents note | 6.3 Genomic Quadruplexes6.4 Quadruplexes in Human Telomeres; 6.5 Quadruplexes as Anticancer Targets -- Evidence from In Vivo Studies; 6.6 Native Quadruplex Structures; 6.7 Quadruplex-Small-Molecule Structures; 6.8 Developing Superior Quadruplex-Binding Ligands; 6.9 Conclusions; References; Chapter 7: Identifying Actionable Targets in Cancer Patients; 7.1 Introduction and Background; 7.2 Overview of Genomic Sequencing and Its Impact on the Identification of Actionable Mutations; 7.3 Actionable Targets by Clinical Molecular Profiling: the OICR / PMH Experience |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Pharmaceutical chemistry. |
Topical term or geographic name as entry element | MEDICAL |
General subdivision | Pharmacology. |
Source of heading or term | bisacsh |
Topical term or geographic name as entry element | Pharmaceutical chemistry. |
Source of heading or term | fast |
Authority record control number | (OCoLC)fst01060115 |
655 #4 - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Electronic books. |
Genre/form data or focus term | Electronic books. |
700 1# - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lackey, Karen. |
Personal name | Roth, Bruce D. |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
Relationship information | Print version: |
Title | Medicinal chemistry approaches to personalized medicine. |
Place, publisher, and date of publication | Weinheim : Wiley-VCH, 2014 |
International Standard Book Number | 9783527677252 |
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
Uniform title | Medicinal chemistry ; |
Volume number/sequential designation | Volume 59. |
856 40 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://onlinelibrary.wiley.com/book/10.1002/9783527677252">http://onlinelibrary.wiley.com/book/10.1002/9783527677252</a> |
Public note | Wiley Online Library [Free Download only for SUST IP] |
938 ## - | |
-- | EBL - Ebook Library |
-- | EBLB |
-- | EBL1569033 |
-- | EBSCOhost |
-- | EBSC |
-- | 668292 |
-- | Ingram Digital eBook Collection |
-- | IDEB |
-- | cis26870791 |
-- | YBP Library Services |
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994 ## - | |
-- | 92 |
-- | DG1 |
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