Antitargets and drug safety / (Record no. 65426)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06220cam a2200817Ia 4500 |
| 001 - CONTROL NUMBER | |
| control field | sulb-eb0033774 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | BD-SySUS |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20170713221417.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu---unuuu |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150307s2015 gw ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EBLCP |
| Language of cataloging | eng |
| Description conventions | pn |
| Transcribing agency | EBLCP |
| Modifying agency | OCLCO |
| -- | RECBK |
| -- | N$T |
| -- | YDXCP |
| -- | IDEBK |
| -- | CDX |
| -- | DG1 |
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| -- | COO |
| -- | DEBBG |
| -- | OCLCQ |
| -- | OHI |
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| 019 ## - | |
| -- | 909907512 |
| -- | 953987850 |
| -- | 960203676 |
| -- | 961625844 |
| -- | 962626284 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783527673643 |
| Qualifying information | (electronic bk.) |
| International Standard Book Number | 3527673644 |
| Qualifying information | (electronic bk.) |
| International Standard Book Number | 9783527673674 |
| Qualifying information | (electronic bk.) |
| International Standard Book Number | 3527673679 |
| Qualifying information | (electronic bk.) |
| Canceled/invalid ISBN | 9783527673667 |
| Canceled/invalid ISBN | 3527673660 |
| Canceled/invalid ISBN | 9783527335114 |
| Canceled/invalid ISBN | 3527335110 |
| 029 1# - OTHER SYSTEM CONTROL NUMBER (OCLC) | |
| OCLC library identifier | CHDSB |
| System control number | 006359936 |
| OCLC library identifier | CHVBK |
| System control number | 332136523 |
| OCLC library identifier | DEBBG |
| System control number | BV042792550 |
| OCLC library identifier | DEBBG |
| System control number | BV043397595 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)904518353 |
| Canceled/invalid control number | (OCoLC)909907512 |
| -- | (OCoLC)953987850 |
| -- | (OCoLC)960203676 |
| -- | (OCoLC)961625844 |
| -- | (OCoLC)962626284 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RS420 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED |
| Subject category code subdivision | 071000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| Edition number | 23 |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | MAIN |
| 245 00 - TITLE STATEMENT | |
| Title | Antitargets and drug safety / |
| Statement of responsibility, etc. | edited by Laszlo Urban, Vinod F. Patel and Roy J. Vaz. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | Weinheim : |
| Name of publisher, distributor, etc. | Wiley-VCH, |
| Date of publication, distribution, etc. | 2015. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (1266 pages). |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 490 1# - SERIES STATEMENT | |
| Series statement | Methods and principles in medicinal chemistry ; |
| Volume/sequential designation | v. 66 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references and index. |
| 588 0# - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Print version record. |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | General Concept for Target-based Safety Assessment. Side Effects of Marketed Drugs: The Utility and Pitfalls of Pharmacovigilance / Steven Whitebread, Mateusz Maciejewski, Alexander Fekete, Eugen Lounkine, László Urbán -- Prediction of Drug Side Effects / Michael J Keiser -- Translational Value of Preclinical Safety Assessment: System Organ Class (SOC) Representation of Off-Targets / Mateusz Maciejewski, Eugen Lounkine, Andreas Hartmann, Steven Whitebread, László Urbán -- Pathological Conditions Associated with the Disturbance of the 5-HT System / Daniel Hoyer -- Hepatic Side Effects. Drug-Induced Liver Injury: Clinical and Diagnostic Aspects / John R Senior -- Mechanistic Safety Biomarkers for Drug-Induced Liver Injury / Daniel J Antoine -- Models for the Prediction of Drug-Induced Liver Injury in Lead Discovery / Frederic Moulin, Oliver Flint -- Transporters in the Liver / Bruno Stieger, Gerd A Kullak-Ublick -- Mechanistic Modeling of Drug-Induced Liver Injury (DILI) / Kyunghee Yang, Jeffrey L Woodhead, Lisl K Shoda, Yuching Yang, Paul B Watkins, Kim LR Brouwer, Brett A Howell, Scott Q Siler -- Cardiovascular Side Effects. Functional Cardiac Safety Evaluation of Novel Therapeutics / Jean-Pierre Valentin, Brian Guth, Robert L Hamlin, Pierre Lainée, Dusty Sarazan, Matt Skinner -- Safety Aspects of the Ca1.2 Channel / Berengere Dumotier, Martin Traebert -- Cardiac Sodium Current (Na1.5) / Gary Gintant -- Circulating Biomarkers for Drug-Induced Cardiotoxicity: Reverse Translation from Patients to Nonclinical Species / Gül Erdemli, Haisong Ju, Sarita Pereira -- The Mechanistic Basis of hERG Blockade and the Proarrhythmic Effects Thereof / Robert A Pearlstein, K Andrew MacCannell, Qi-Ying Hu, Ramy Farid, José S Duca -- Kinase Antitargets. Introduction to Kinase Antitargets / Mark C Munson -- Clinical and Nonclinical Adverse Effects of Kinase Inhibitors / Douglas A Keller, Richard J Brennan, Karen L Leach -- Cardiac Side Effects Associated with Kinase Proteins and Their Signaling Pathways / Roy J Vaz, Vinod F Patel -- Case Studies: Selective Inhibitors of Protein Kinases : Exploiting Demure Features / Ellen R Laird -- Examples of Clinical Translation. Torcetrapib and Dalcetrapib Safety: Relevance of Preclinical and Models / Eric J Niesor, Andrea Greiter-Wilke, Lutz Müller -- Targets Associated with Drug-Related Suicidal Ideation and Behavior / Andreas Hartmann, Steven Whitebread, Jacques Hamon, Alexander Fekete, Christian Trendelenburg, Patrick Y Müller, László Urbán. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Drug development. |
| Topical term or geographic name as entry element | Drugs |
| General subdivision | Design. |
| Topical term or geographic name as entry element | Drugs |
| General subdivision | Side effects. |
| Topical term or geographic name as entry element | Drug interactions. |
| Topical term or geographic name as entry element | Drug development. |
| Topical term or geographic name as entry element | Drugs |
| General subdivision | Design. |
| Topical term or geographic name as entry element | Medicine. |
| Topical term or geographic name as entry element | MEDICAL |
| General subdivision | Pharmacology. |
| Source of heading or term | bisacsh |
| Topical term or geographic name as entry element | Drug development. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst00898670 |
| Topical term or geographic name as entry element | Drug interactions. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst00898681 |
| Topical term or geographic name as entry element | Drugs |
| General subdivision | Design. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst00898790 |
| Topical term or geographic name as entry element | Drugs |
| General subdivision | Side effects. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst00898912 |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Urbán, László. |
| Personal name | Patel, Vinod F. |
| Personal name | Vaz, Roy J. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Urban, Laszlo. |
| Title | Antitargets and Drug Safety. |
| Place, publisher, and date of publication | Hoboken : Wiley, ©2015 |
| International Standard Book Number | 9783527335114 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Methods and principles in medicinal chemistry ; |
| Volume number/sequential designation | v. 66. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://onlinelibrary.wiley.com/book/10.1002/9783527673643">http://onlinelibrary.wiley.com/book/10.1002/9783527673643</a> |
| Public note | Wiley Online Library [Free Download only for SUST IP] |
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