Molecular basis of oxidative stress : chemistry, mechanisms, and disease pathogenesis / edited by Frederick A. Villamena, Department of Pharmacology and Davis Heart and Lung Institute, the Ohio State University, Columbus, Ohio, USA.

Includes bibliographical references and index.

Print version record and CIP data provided by publisher.

Focusing on the molecular and chemical bases of oxidative stress, which can cause cancer as well as cardiovascular and neurodegenerative diseases, Molecular Basis of Oxidate Stress discusses the role of free radicals in disease, diagnosis, and therapeutics. Written by recognized leaders in the field, the book provides in-depth knowledge about the mechanisms of oxidative stress and damage, free radical chemistry, and the role of free radicals in disease, diagnosis, and therapeutics.

""Title page""; ""Copyright page""; ""Preface""; ""About the Contributors""; ""Contributors""; ""1: Chemistry of Reactive Species""; ""1.1 Redox Chemistry""; ""1.2 Classification of Reactive Species""; ""1.3 Reactivity""; ""1.4 Origins of Reactive Species""; ""1.5 Methods of Detection""; ""2: Lipid Peroxidation and Nitration""; ""Overview""; ""2.1 Peroxidation of PUFAs""; ""2.2 Cyclic Endoperoxides and Their Products""; ""2.3 Fragmented Products of Lipid Peroxidation""; ""2.4 Epoxy Fatty Acids""; ""2.5 Lipid Nitrosylation""; ""Summary""; ""3: Protein Posttranslational Modification""

""Overview""""3.1 Oxidative Stress-Related PTMs: Oxidation Reactions""; ""3.2 Amino Acid Modification by Oxidation-Produced Electrophiles""; ""3.3 Detection of Oxidative-Stress Related PTM""; ""3.4 Role of PTMs in Cellular Redox Signaling""; ""Summary""; ""4: DNA Oxidation""; ""Overview""; ""4.1 The Context of Cellular DNA Oxidation""; ""4.2 Oxidation of Oligonucleotides""; ""4.3 Examination of Specific Oxidative Lesions""; ""Future Outlook of DNA Oxidative Lesions""; ""5: Downregulation of Antioxidants and Phase 2 Proteins""; ""Overview""

""5.1 Definitions of Antioxidants and Phase 2 Proteins""""5.2 Roles in Oxidative Stress""; ""5.3 Molecular Regulation""; ""5.4 Induction in Chemoprevention""; ""5.5 Downregulation""; ""Conclusions and Perspectives""; ""6: Mitochondrial Dysfunction""; ""Overview""; ""6.1 Mitochondria and Submitochondrial Particles""; ""6.2 Energy Transduction""; ""6.3 Mitochondrial Stress""; ""6.4 Superoxide Radical Anion Generation as Mediated by ETC and Disease Pathogenesis""; ""Summary""; ""7: NADPH Oxidases: Structure and Function""; ""Overview""; ""7.1 Introduction""

""7.2 Phagocyte NADPH Oxidase Structure""""7.3 Phagocyte ROS Production""; ""7.4 Phagocyte NADPH Oxidase Function""; ""7.5 Nonphagocyte NADPH Oxidase Structure""; ""7.6 Nonphagocyte ROS Production""; ""7.7 Functions of Nonphagocyte NADPH Oxidases""; ""Summary""; ""Acknowledgments""; ""8: Cell Signaling and Transcription""; ""Overview""; ""8.1 Common Mechanisms of Redox Signaling""; ""8.2 Redox and Oxygen-Sensitive Transcription Factors in Prokaryotes""; ""8.3 Redox Signaling in Metazoans""; ""8.4 Oxygen Sensing in Metazoans""; ""8.5 Medical Significance of Redox and Oxygen-Sensing Pathways""

""Concluding Remarks""""9: Oxidative Stress and Redox Signaling in Carcinogenesis""; ""Overview""; ""9.1 Redox Environment and Cancer""; ""9.2 Oxidative Modifications to Biomolecules and Carcinogenesis""; ""9.3 Measurement of Oxidative DNA Damage in Human Cancer""; ""9.4 Epigenetic Involvement in Oxidative Stress-Induced Carcinogenesis""; ""9.5 Deregulation of Cell Death Pathways by Oxidative Stress in Cancer Progression""; ""Conclusions and Perspective""; ""Acknowledgments""; ""10: Neurodegeneration from Drugs and Aging-Derived Free Radicals""; ""Overview""; ""10.1 ROS Formation""