TY  - BOOK
AU  - Siehler,Sandra
AU  - Milligan,Graeme
TI  - G Protein-Coupled Receptors: Structure, Signaling, and Physiology 
SN  - 9780511760334 (ebook)
AV  - QP552.G16 G1747 2011
U1  - 572/.696 22
PY  - 2010///
CY  - Cambridge
PB  - Cambridge University Press
KW  - G proteins
KW  - Cell receptors
KW  - Cellular signal transduction
KW  - Drug Delivery Systems
N1  - Title from publisher's bibliographic system (viewed on 04 Apr 2016)
N2  - Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field
UR  - http://dx.doi.org/10.1017/CBO9780511760334
ER  -