TY  - BOOK
AU  - Borisova,Tatiana
ED  - SpringerLink (Online service)
TI  - Cholesterol and Presynaptic Glutamate Transport in the Brain
T2  - SpringerBriefs in Neuroscience,
SN  - 9781461477594
AV  - RC321-580 
U1  - 612.8 23
PY  - 2013///
CY  - New York, NY
PB  - Springer New York, Imprint: Springer
KW  - Medicine
KW  - Neurosciences
KW  - Neurochemistry
KW  - Biomedicine
N1  - Presynaptic glutamate transport in the brain -- Cholesterol and its role in synaptic transmission -- Effects of cholesterol-depleting agent methyl-b-cyclodextrin (MbCD) on the functional state of brain nerve terminals -- The extracellular level and uptake of glutamate in cholesterol-deficient nerve terminals -- Unstimulated and exocytotic glutamate release from cholesterol-deficient nerve terminals -- Neuroprotection by lowering cholesterol
N2  - Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders.  Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced levels of cholesterol have been implicated in the pathogenesis of disorders such as stroke, ischemia, traumatic brain injury, and neurotoxicity.   In the proposed book, the author presents data from the literature and from her own lab to address the extent to and way in which membrane cholesterol modulates presynaptic glutamate transport and whether lowering the level of cholesterol available can offer some neuroprotective benefits
UR  - http://dx.doi.org/10.1007/978-1-4614-7759-4
ER  -