TY  - BOOK
AU  - Barrett,Lucy W.
AU  - Fletcher,Sue
AU  - Wilton,Steve D.
ED  - SpringerLink (Online service)
TI  - Untranslated Gene Regions and Other Non-coding Elements: Regulation of Eukaryotic Gene Expression 
T2  - SpringerBriefs in Biochemistry and Molecular Biology,
SN  - 9783034806794
AV  - QH432 
U1  - 591.35 23
PY  - 2013///
CY  - Basel
PB  - Springer Basel, Imprint: Springer
KW  - Life sciences
KW  - Medical genetics
KW  - Nucleic acids
KW  - Plant genetics
KW  - Animal genetics
KW  - Life Sciences
KW  - Animal Genetics and Genomics
KW  - Plant Genetics & Genomics
KW  - Gene Function
KW  - Nucleic Acid Chemistry
N1  - Introduction -- Promoter -- 5’ Untranslated Region -- Structure -- Intronic Regions -- 3’ Untranslated Region -- Non-coding RNAs -- Conclusion
N2  - There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution
UR  - http://dx.doi.org/10.1007/978-3-0348-0679-4
ER  -