TY  - BOOK
AU  - Byers,B.Rowe
ED  - SpringerLink (Online service)
TI  - Iron Acquisition by the Genus Mycobacterium: History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development 
T2  - SpringerBriefs in Molecular Science,
SN  - 9783319003030
AV  - QR1-502 
U1  - 579 23
PY  - 2013///
CY  - Heidelberg
PB  - Springer International Publishing, Imprint: Springer
KW  - Life sciences
KW  - Inorganic chemistry
KW  - Bioorganic chemistry
KW  - Infectious diseases
KW  - Proteins
KW  - Microbiology
KW  - Life Sciences
KW  - Protein-Ligand Interactions
KW  - Inorganic Chemistry
KW  - Bioorganic Chemistry
KW  - Infectious Diseases
N1  - A History of Iron Metabolism in the Mycobacteria -- Mycobacterial Iron Uptake Mechanisms -- Siderocalin Combats Mycobacterial Infections -- Design of Anti-TB Drugs Using the Iron Uptake Platform
N2  - Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates
UR  - http://dx.doi.org/10.1007/978-3-319-00303-0
ER  -