TY  - BOOK
AU  - Fischer,János
AU  - Ganellin,C.R.
AU  - Rotella,David P.
TI  - Analogue-based drug discovery III
SN  - 9783527651085
AV  - RM301.25 .A53 2013
U1  - 615.1/9 23
PY  - 2013///]
CY  - Weinheim
PB  - Wiley-VCH
KW  - Drug development
KW  - MEDICAL
KW  - Drug Guides
KW  - bisacsh
KW  - Nursing
KW  - Pharmacology
KW  - Pharmacy
KW  - fast
KW  - Electronic books
KW  - local
N1  - Includes bibliographical references and index; General Aspects. Pioneer and Analogue Drugs; Janos Fischer, C Robin Ganellin, David P Rotella --; Competition in the Pharmaceutical Drug Development; Christian Tyrchan, Fabrizio Giordanetto --; Metabolic Stability and Analogue-Based Drug Discovery; Amit S Kalgutkar, Antonia F Stepan --; Use of Macrocycles in Drug Design Exemplified with Ulimorelin, a Potential Ghrelin Agonist for Gastrointestinal Motility Disorders; Mark L Peterson, Hamid Hoveyda, Graeme Fraser, Eric Marsault, Rene Gagnon --; Drug Classes. The Discovery of Anticancer Drugs Targeting Epigenetic Enzymes; A Ganesan --; Thienopyridyl and Direct-Acting P2Y Receptor Antagonist Antiplatelet Drugs; Joseph A Jakubowski, Atsuhiro Sugidachi --; Selective Estrogen Receptor Modulators; Amarjit Luniwal, Rachael Jetson, Paul Erhardt --; Discovery of Nonpeptide Vasopressin V2 Receptor Antagonists; Kazumi Kondo, Hidenori Ogawa --; The Development of Cysteinyl Leukotriene Receptor Antagonists; Peter R Bernstein --; Case Studies. The Discovery of Dabigatran Etexilate; Norbert Hauel, Andreas Clemens, Herbert Nar, Henning Priepke, Joanne van Ryn, Wolfgang Wienen --; The Discovery of Citalopram and Its Refinement to Escitalopram; Klaus P Bogeso, Connie Sanchez --; Tapentadol : From Morphine and Tramadol to the Discovery of Tapentadol; Helmut Buschmann --; Novel Taxanes: Cabazitaxel Case Study; Herve Bouchard, Dorothee Semiond, Marie-Laure Risse, Patricia Vrignaud --; Discovery of Boceprevir and Narlaprevir: A Case Study for Role of Structure-Based Drug Design; Srikanth Venkatraman, Andrew Prongay, George F Njoroge --; A New-Generation Uric Acid Production Inhibitor: Febuxostat; Ken Okamoto, Shiro Kondo, Takeshi Nishino
N2  - "Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs. The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and--together with the previous volumes--constitutes the first systematic approach to drug analogue development"--Publisher's website
UR  - http://onlinelibrary.wiley.com/book/10.1002/9783527651085
ER  -