TY  - BOOK
AU  - Keserü,G.M.
AU  - Swinney,David Carl
TI  - Thermodynamics and kinetics of drug binding
T2  - Methods and principles in medicinal chemistry
SN  - 9783527673049
AV  - RM301.25 .T44 2015eb
U1  - 615.19 23
PY  - 2015///]
CY  - Weinheim, Germany
PB  - Wiley-VCH Verlag GmbH & Co. KGaA
KW  - Drug development
KW  - Binding sites (Biochemistry)
KW  - Thermodynamics
KW  - Pharmacokinetics
KW  - MEDICAL / Pharmacology
KW  - bisacsh
KW  - fast
KW  - Drug Discovery
KW  - Receptors, Drug
KW  - Ligands
KW  - Electronic books
N1  - Includes bibliographical references and index
N2  - "This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors."--
UR  - http://onlinelibrary.wiley.com/book/10.1002/9783527673025
ER  -