TY - BOOK AU - Alex,Alexander A. AU - Harris,C.John AU - Smith,Dennis A. TI - Attrition in the pharmaceutical industry: reasons, implications, and pathways forward SN - 9781118914342 (epub) AV - HD9665.5 U1 - 615.1068/5 23 PY - 2015/// CY - Hoboken, New Jersey PB - John Wiley & Sons KW - Pharmaceutical industry KW - Management KW - Capital productivity KW - Industrial efficiency KW - Drug development KW - fast KW - MEDICAL / Pharmacology KW - bisacsh KW - Electronic books N1 - Includes index; Attrition in drug discovery and development / Scott Boyer, Clive Brealey and Andrew M. Davis -- Compound attrition at the pre-clinical phase / Cornelis E.C.A. Hop -- Attrition in phase I / Dennis A. Smith and Thomas A. Baillie -- Compound attrition in phase II/III / Alexander Alex, C. John Harris, Wilma W. Keighley and Dennis A. Smith -- Post-marketing attrition / Dennis A. Smith -- Influence of the regulatory environment on attrition / Robert T. Clay -- Experimental screening strategies to reduce attrition risk / Marie-Claire Peakman, Matthew Troutman, Rose Gonzales and Anne Schmidt -- Medicinal chemistry strategies to prevent compound attrition / J. Richard Morphy -- Influence of phenotypic and target-based screening strategies on compound attrition and project choice / Andrew Bell, Wolfgang Fecke and Christine Williams -- In silico approaches to address compound attrition / Peter Gedeck, Christian Kramer, Richard Lewis -- Current and future strategies for improving drug discovery efficiency / Peter Mbugua Njogu and Kelly Chibale -- Impact of investment strategies, organizational structure and corporate environment on attrition, and future investment strategies to reduce attrition / Geoff Lawton UR - http://onlinelibrary.wiley.com/book/10.1002/9781118819586 ER -