TY - BOOK AU - Dunlap,Norma AU - Huryn,Donna M. TI - Medicinal chemistry SN - 9780815345565 U1 - 615.19 23 PY - 2018///] CY - New York , NY PB - Garland Science, Taylor & Francis Group, LLC KW - Pharmaceutical chemistry KW - Chemotherapy N1 - Historical perspective and overview of drug discovery -- Drug discovery: hit and lead discovery -- Drug discovery: optimization of lead properties -- Medicinal chemistry strategies used in lead optimization -- The process of developing a drug from an optimized lead: -- Receptors as drug targets -- Enzymes as drug targets -- Protein-protein interactions and lipids as drug targets -- DNA and RNA as drug targets -- Anti-cancer drugs -- Infectious diseases I: antiviral and antifungal drugs -- Infectious diseases II: antibacterial and antiparasitic drugs -- Drugs acting on the CNS ER -