TY  - BOOK
AU  - Barańska,Jolanta
ED  - SpringerLink (Online service)
TI  - Glioma Signaling
T2  - Advances in Experimental Medicine and Biology,
SN  - 9789400747197
AV  - R-RZ 
U1  - 610 23
PY  - 2013///
CY  - Dordrecht
PB  - Springer Netherlands, Imprint: Springer
KW  - Medicine
KW  - Cancer research
KW  - Molecular biology
KW  - Neurosciences
KW  - Biomedicine
KW  - Biomedicine general
KW  - Cancer Research
KW  - Molecular Medicine
N2  - Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumors, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. Glioma Signaling is a text reference on cellular signaling processes regulating gliomas physiology and invasiveness. The first half of the book is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides. The remaining chapters deal with the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration, cellular growth, progression and invasion, as well as presents perspectives concerning potential targets for glioma therapy
UR  - http://dx.doi.org/10.1007/978-94-007-4719-7
ER  -