TY - BOOK AU - Dey,Aparajita ED - SpringerLink (Online service) TI - Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism T2 - Subcellular Biochemistry, SN - 9789400758810 AV - RM1-950 U1 - 615 23 PY - 2013/// CY - Dordrecht PB - Springer Netherlands, Imprint: Springer KW - Medicine KW - Pharmacology KW - Life sciences KW - Biochemistry KW - Biomedicine KW - Pharmacology/Toxicology KW - Life Sciences, general KW - Biochemistry, general N1 - Cytochrome P450 2E1 and its clinical aspects -- Nrf2 and antioxidant defense against CYP2E1 toxicity -- The role of Cytochrome P-4502E1 in ethanol-mediated carcinogenesis -- The Importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome -- Relevance of CYP2E1 to non-alcoholic fatty liver disease -- CYP2E1-catalyzed alcohol metabolism -- CYP2E1, oxidative stress, post-translational modifications and  lipid metabolism -- The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system N2 - The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1), which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities, which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of the central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications UR - http://dx.doi.org/10.1007/978-94-007-5881-0 ER -