Stem cell epigenetics / edited by Eran Meshorer, Giuseppe Testa.

Includes bibliographical references and index.

Epigenetic processes and DNA repair in embryonic stem cells -- The epigenetics of pluripotent stem cells -- A change in culture : modelling human germ cell development in vitro -- Chromatin architecture and topology in pluripotent stem cells - The pluripotent cell cycle-- Mitotic bookmarking by transcription factors and the preservation of pluripotency -- Roles and regulation of endogenous retroviruses in pluripotency and early development -- Single-cell technologies in stem cell epigenetics -- Chromatin plasticity in pluripotent an cancer stem cells -- Transcriptional and epigenetic regulatory mechanisms in glioblastoma stem cells -- Three- dimensional models of human brain development -- The role of chromatin modifiers in common neurodevelopmental disorders.

Growing evidence suggests that epigenetic mechanisms play a central role in stem cell biology and are vital for determining gene expression during cellular differentiation and governing mammalian development. In Stem Cell Epigenetics, leading international researchers examine how chromatin regulation and bona fide epigenetic mechanisms underlie stem cell renewal and differentiation. Authors also explore how the diversity of cell types, including the extent revealed by single cell omic approaches, is achieved, and how such processes may be reversed or managed via epigenetic reprogramming. Topics discussed include chromatin in pluripotency, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, stem cells and cancer, epigenetics and disease modeling, brain organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the book discusses the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment. Stem Cell Epigenetics will provide researchers and physicians with a state-of-the-art map to orient across the frontiers of this fast-evolving field. Key features: Analyzes the role of epigenetics in embryonic stem cell regulation; Indicates the epigenetic mechanisms involved in stem cell differentiation and highlights modifications and misregulations that may result in disease pathogenesis; Examines the potential applications of stem cell epigenetics in therapeutic disease interventions and regenerative medicine, providing a foundation for researchers and physicians to bring this exciting and fast-evolving field into a clinical setting; Features chapter contributions by leading international experts. -- Back cover.