Novel delivery systems for transdermal and intradermal drug delivery / Ryan F. Donnelly, Thakur Raghu Raj Singh.

Includes bibliographical references and index.

Introduction / Gary P.J. Moss -- Application of spectroscopic techniques to interrogate skin / Jonathan Hadgraft, Rita Mateus and Majella E. Lane -- Analysis of the native structure of the skin barrier by cryo-tem combined with em-simulation / Lars Norlen -- Intradermal vaccination / Marija Zaric and Adrien Kissenpfennig -- Film forming and heated systems / William J. McAuley -- Nanotechnology-based applications for transdermal delivery of therapeutics / Venkata K Yellepeddi -- Magnetophoresis and electret mediated transdermal delivery of drugs / Abhijeet Maurya, Cui Lili and S.Narasimha Murthy -- Microporation for enhanced transdermal drug delivery / Thakur Raghu Raj Singh, Gujral C -- Microneedle technology / Helen L. Quinn, Aaron J. Courtenay, Mary-Carmel Kearney and Ryan F. Donnelly -- Intradermal delivery of active cosmeceutical ingredients / Andrzej M. Bugaj -- Commercial and regulatory considerations in transdermal and dermal medicines development / Marc .B. Brown, Jon Lenn, Charles Evans, Sian Lim.

Description based on print version record and CIP data provided by publisher.

This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation. Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.