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008 120828s2013 xxu| s |||| 0|eng d
020 _a9781461439585
_9978-1-4614-3958-5
024 7 _a10.1007/978-1-4614-3958-5
_2doi
050 4 _aQD431-431.7
072 7 _aPSBC
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572.6
_223
100 1 _aMorré, D. James.
_eauthor.
245 1 0 _aECTO-NOX Proteins
_h[electronic resource] :
_bGrowth, Cancer, and Aging /
_cby D. James Morré, Dorothy M. Morré.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXVI, 508 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- The ECTO-NOX protein family -- Measurement of ECTO-NOX (ENOX) activities -- The constitutive ENOX1 (CNOX) -- Role in plasma membrane electron transport -- Role in the enlargement phase of cell growth -- Role as ultradian oscillators of the cells’ biological clock -- Other potential functional roles of ENOX proteins -- ENOX2 (tNOX) and cancer -- Age-related ENOX proteins (arNOX) -- The auxin-stimulated ENOX and auxin-stimulation of plant growth -- Cancer therapeutic applications of ENOX2 proteins -- Diagnostic applicastions of ENOX2 proteins -- Appendix A Epilogue: Remaining challenges -- Appendix B Detailed description of 2-D gel electrophoresis western blot early detection protocol.
520 _a"ENOX Proteins" documents a unique family of cell surface proteins which are the exclusive discovery (subsequently confirmed by others) of the authors, their students and their colleagues. An ENOX-based mechanism is provided for how cells increase in size that is both unique and applicable not only to cancer and cancer therapy but also to production agriculture and biomass increase. The role of ENOX proteins in biological time-keeping is described along with evidence for oscillations in the ratios of electron spin pairs defining ortho and para water states that form highly coordinated populations of coherent water of interest to physicists as the underlying mechanism. The age-related NADH oxidases that appear around age 30 and increase steadily thereafter with potentially causal involvements in atherogenesis and skin aging have been identified as five members of the TM-9 protein superfamily of all with different chromosomal locations. The arNOX proteins initially are membrane anchored but functionally-active N-terminal fragments that are shed into body fluids. Except for critical functional motifs, all of the ENOX protein family members have distinct protein sequences and chromosomal origins. A fourth member of the ENOX protein family occurs in plants as the primary target for both natural and synthetic growth hormone (auxin)-stimulated rapid cell enlargement. Despite masquerading as intractable and difficult to clone and characterize, ENOX proteins offer remarkable opportunities for research, commercial development and outside confirmation of new paradigms to help explain complex biological processes.
650 0 _aLife sciences.
650 0 _aCancer research.
650 0 _aPlant biochemistry.
650 0 _aProteomics.
650 0 _aProteins.
650 0 _aCytokines.
650 0 _aGrowth factors.
650 0 _aCell biology.
650 1 4 _aLife Sciences.
650 2 4 _aProtein Science.
650 2 4 _aProteomics.
650 2 4 _aCell Biology.
650 2 4 _aCytokines and Growth Factors.
650 2 4 _aCancer Research.
650 2 4 _aPlant Biochemistry.
700 1 _aMorré, Dorothy M.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461439578
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-3958-5
912 _aZDB-2-SBL
942 _2Dewey Decimal Classification
_ceBooks
999 _c43994
_d43994