000			04386nam a22005777a 4500
001			sulb-eb0021910
003			BD-SySUS
005			20160413122210.0
007			cr nn 008mamaa
008			120919s2013 xxu| s |||| 0|eng d
020			_a9781461439912 _9978-1-4614-3991-2
024	7		_a10.1007/978-1-4614-3991-2 _2doi
050		4	_aQP110.G45
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
072		7	_aSCI029000 _2bisacsh
082	0	4	_a611.01816 _223
245	1	0	_aBiophysical approaches to translational control of gene expression _h[electronic resource] / _cedited by Jonathan D. Dinman.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXII, 320 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aBiophysics for the Life Sciences ; _v1
505	0		_aX-ray analysis of prokaryotic and eukaryotic ribosomes -- A passage through the ribosome by Cryo-EM -- Molecular dynamics simulations of the ribosome -- Structural analyses of the ribosome by chemical modification methods -- Methods for studying the interactions of translation factors with the ribosome -- Riboproteomic approaches to understanding IRES elements -- Rapid kinetic analysis of protein synthesis -- Investigating RNAs Involved in Translational Control by NMR and SAXS -- Analyses of RNA-ligand interactions by fluorescence anisotropy -- Approaches for the Identification and Characterization of RNA-Protein Interactions -- A multidisciplinary approach to RNA Localization -- Virtual Screening for RNA-interacting Small Molecules -- The ‘fifth’ RNA nucleotide: a role for ribosomal RNA pseudouridylation in control of gene expression at the translational level -- Translational Control of Synaptic Plasticity and Memory.
520			_aWhen quantum mechanics was first proposed a century ago, nobody could have anticipated how deeply it would affect our lives.  Today, we are connected and powered through devices whose existence is predicated on the basic principles of this strange physics.  Not even the biological sciences have escaped its reach.  As scientists query the deepest mysteries of the living world, the physical scales probed and the types of questions asked are increasingly blurring the lines between biology and physics.  The hybrid field of biophysics represents the new frontier of the 21st century. The ribosome has been at the heart of three Nobel Prizes.  Understanding its essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis has been one of the central foundations in our understanding of the biology at the molecular level.  With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm. This book provides a premier resource to a wide audience, whether it be the general reader seeking a broad view of the field, a clinician interested in the role of protein translation in human disease, the bench researcher looking for state-of-the-art technologies, or computational scientists involved in cutting edge molecular modeling.
650		0	_aMedicine.
650		0	_aGene expression.
650		0	_aBiochemistry.
650		0	_aNucleic acids.
650		0	_aCrystallography.
650		0	_aBiophysics.
650		0	_aBiological physics.
650	1	4	_aBiomedicine.
650	2	4	_aGene Expression.
650	2	4	_aBiophysics and Biological Physics.
650	2	4	_aBiochemistry, general.
650	2	4	_aSingle Molecule Studies, Molecular Motors.
650	2	4	_aNucleic Acid Chemistry.
650	2	4	_aCrystallography.
700	1		_aDinman, Jonathan D. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461439905
830		0	_aBiophysics for the Life Sciences ; _v1
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-3991-2
912			_aZDB-2-SBL
942			_2Dewey Decimal Classification _ceBooks
999			_c44002 _d44002