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003 BD-SySUS
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008 121206s2013 xxu| s |||| 0|eng d
020 _a9781461453260
_9978-1-4614-5326-0
024 7 _a10.1007/978-1-4614-5326-0
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
245 1 0 _aMucosal Immunology of Acute Bacterial Pneumonia
_h[electronic resource] /
_cedited by Alice Prince.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aX, 278 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aAlveolar macrophages – key coordinators of host defense -- Lung dendritic cells and pulmonary defense mechanisms against bacteria -- CD4 T cell immunity in the lung -- Neutrophil mediated defenses in bacterial pneumonia -- Toll-like receptors in the epithelium -- Type I IFN signaling in bacterial pneumonia -- Transcriptional signaling hubs in epithelial cells during pneumonia.- Innate immune responses in Ventilator Associated Pneumonia -- Streptococcus pneumoniae: The prototype of lung responses in pneumonia -- Staphylococcus aureus infection of the respiratory tract -- Pseudomonas aeruginosa: the consummate opportunistic pathogen of the lung.  .
520 _aIn contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens.  The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections.  It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae.   By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMedical microbiology.
650 0 _aInfectious diseases.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aMedical Microbiology.
650 2 4 _aInfectious Diseases.
700 1 _aPrince, Alice.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461453253
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-5326-0
912 _aZDB-2-SBL
942 _2Dewey Decimal Classification
_ceBooks
999 _c44341
_d44341