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008 130417s2013 xxu| s |||| 0|eng d
020 _a9781461453802
_9978-1-4614-5380-2
024 7 _a10.1007/978-1-4614-5380-2
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
245 1 0 _aNovel Immune Potentiators and Delivery Technologies for Next Generation Vaccines
_h[electronic resource] /
_cedited by Manmohan Singh.
264 1 _aBoston, MA :
_bSpringer US :
_bImprint: Springer,
_c2013.
300 _aX, 370 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aCritical parameters that govern the optimization of vaccine formulations -- Development of Biophysical assays to better understand vaccine formulation stability -- Rational design of vaccine formulations -- Monitoring stability and efficacy of multi-valent vaccine formulations.-  Overcoming challenges of multi component alum formulations.-  Delivery of various TLR adjuvants using alum platform -- History of use of emulsions for vaccine delivery -- MF59 o/w emulsion : History and safety over the last 2 decades -- Optimizing novel nanoemulsions for delivery of next generation antigens and adjuvants -- Modulating vaccine responses with innate immunity : Use of PLGA nanoparticles for delivering multiple TLR agonists -- Shape matters : Role of nanoparticle shape in induction of immune responses to a vaccine.        .
520 _aDevelopment of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMedical microbiology.
650 0 _aVaccines.
650 0 _aPharmaceutical technology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aMedical Microbiology.
650 2 4 _aVaccine.
650 2 4 _aPharmaceutical Sciences/Technology.
700 1 _aSingh, Manmohan.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461453796
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-5380-2
912 _aZDB-2-SBL
942 _2Dewey Decimal Classification
_ceBooks
999 _c44355
_d44355