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008 130127s2013 xxu| s |||| 0|eng d
020 _a9781461454380
_9978-1-4614-5438-0
024 7 _a10.1007/978-1-4614-5438-0
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aPathobiology of Cancer Regimen-Related Toxicities
_h[electronic resource] /
_cedited by Stephen T. Sonis, Dorothy M. Keefe.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aX, 292 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface.-Epidemiology and outcomes of regimen-related toxicities -- The biological basis for differences in normal tissue response to radiation therapy and strategies to establish predictive assays for individual complication risk -- The bystander effect: Ionizing radiation-induced non-targeted effects: Evidence, mechanism and significance -- The role of genes on the metabolism of chemotherapeutic agents and their impact on toxicity.-  Animal models of regimen-related toxicities -- Nausea and Vomiting -- Mucositis -- Dermatitis and Alopecia.-  Fibrosis.-  Myelosuppression -- Neuropathy -- Fatigue -- Xerostomia -- Osteonecrosis -- Conclusions and therapeutic opportunities -- Index.
520 _aToxicities have been consistent undesirable companions of every form of radiation and drug cancer treatment regimens.  In addition to the potential for toxicities to devastate patients’ quality of life, they generate huge incremental financial costs, and sap patients’ ability to tolerate definitive cancer therapy.   And every new drug or biological has come with new side effects.   Historically, regimen-related toxicities were viewed as the inevitable cost of treating cancer.  But this may be about to change. Discoveries in the past dozen years have painted a new picture of the pathobiology of almost all regimen-related toxicities.  The mechanistic complexities that underlie radiation- and chemotherapy-induced tissue injury or systemic symptoms have been pieced together in an incremental sequence which now provides multiple targets for effective toxicity interventions. This book brings together, for the first time in a single volume, the most current information regarding both general principles guiding current thinking about the pathogenesis of regimen-related toxicities and the specific biological underpinnings of the most common side effects of cancer therapy.  The contents provide information that is essential to clinicians and basic and translational scientists interested in cancer therapy and its toxicities.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aPharmacology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aPharmacology/Toxicology.
700 1 _aSonis, Stephen T.
_eeditor.
700 1 _aKeefe, Dorothy M.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461454373
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-5438-0
912 _aZDB-2-SBL
942 _2Dewey Decimal Classification
_ceBooks
999 _c44370
_d44370