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001			sulb-eb0022500
003			BD-SySUS
005			20160413122301.0
007			cr nn 008mamaa
008			130321s2013 xxu| s |||| 0|eng d
020			_a9781461462804 _9978-1-4614-6280-4
024	7		_a10.1007/978-1-4614-6280-4 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
245	1	0	_aStress-Induced Mutagenesis _h[electronic resource] / _cedited by David Mittelman.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXV, 275 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPreface -- Stress-induced mutagenesis in bacteria -- Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress -- Transcription-mediated mutagenic processes -- Transposon mutagenesis in disease, drug discovery and bacterial evolution -- Hsp90 as a capacitor of both genetic and epigenetic changes in the genome during cancer progression and evolution -- Inheritance of stress-induced epigenetic changes mediated by the ATF-2 family of transcription factors -- Microsatellite Repeats: Canaries in the Coalmine -- Genetic instability Induced by hypoxic stress -- Radiation-induced delayed genome Instability and hypermutation in mammalian cells -- Radiation-induced bystander effects and stress-induced mutagenesis -- Stress induced mutagenesis, genetic diversification, and cell survival via anastasis, the reversal of late stage apoptosis -- The transgenerational effects of parental exposure to mutagens in mammals -- Revisiting mutagenesis in the age of high-throughput sequencing -- Index.
520			_aThe discoveries of stress-induced mutation and epigenetic inheritance have challenged the claim of independence between the evolutionary forces of mutation and selection. In “Stress-Induced Mutagenesis”, leading experts provide the key evidence for and the molecular details of stress-induced genetic and epigenetic mutation, integrating cross-disciplinary observations from a number of species and biological systems, including human. The observations have vast implications for evolutionary biology but also for human medicine. A comprehensive understanding of stress-induced mutagenesis and the processes underlying evolvability, will enable gains in the treatment and management of cancer, as well as other human disorders that result from damaged or unstable genomes.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aBiochemistry.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aBiochemistry, general.
650	2	4	_aBiomedicine general.
700	1		_aMittelman, David. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461462798
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-6280-4
912			_aZDB-2-SBL
942			_2Dewey Decimal Classification _ceBooks
999			_c44592 _d44592