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007 cr nn 008mamaa
008 131021s2013 xxu| s |||| 0|eng d
020 _a9781461464860
_9978-1-4614-6486-0
024 7 _a10.1007/978-1-4614-6486-0
_2doi
050 4 _aRS380
050 4 _aRS190-210
072 7 _aTDCW
_2bicssc
072 7 _aMED072000
_2bisacsh
082 0 4 _a615.19
_223
245 1 0 _aPharmaceutical Biotechnology
_h[electronic resource] :
_bFundamentals and Applications /
_cedited by Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm.
250 _a4th ed. 2013.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXXI, 544 p. 240 illus., 222 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aMolecular Biotechnology: From DNA sequence to therapeutic protein.- Biophysical and Biochemical Analysis of Recombinant Proteins.- Production and purification of Recombinant Proteins -- Formulation of Biotech Products, including Biopharmaceutical Considerations.- Pharmacokinetics and Pharmacodynamics of Peptide and Protein Therapeutics.- Immunogenicity of Therapeutic Proteins -- Monoclonal Antibodies: From Structure to Therapeutic Application -- Genomics, Other “Omics” Technologies, Personalized Medicine and Additional Biotechnology-Related Techniques -- Dispensing Biotechnology Products: Handling, Professional Education and Product Information -- Economic Considerations in Medical Biotechnology -- Regulatory Framework for Biosimilars -- Insulin -- Follicle-Stimulating Hormone -- Human Growth Hormone -- Recombinant Coagulation Factors And Thrombolytic Agents -- Recombinant Human Deoxyribonuclease I.- Monoclonal Antibodies in Cancer -- Hematopoietic Growth Factors: Focus on Erythropoiesis-Stimulating Agents -- Monoclonal Antibodies in Solid Organ Transplantation.- Interferons and Interleukins -- Vaccines.- Oligonucleotides -- Gene Therapy -- Stem Cell Technology.              .
520 _aSetting the standard for modern biopharmaceutical education, the new Fourth Edition is a completely revised text to reflect the rapid growth in the importance of biopharmaceuticals and the techniques of biotechnologies to modern medicine and the life sciences.  The editors have provided a well-balanced framework for introductory as well as more detailed education in various aspects of pharmaceutical biotechnology and the production, biopharmaceutics, and clinical pharmacology of biotechnology-produced drugs.  The new edition improves upon the strong chapters of previous editions, adding emergent trends and cutting-edge advances as well as new graphic illustrations and new authors.  The textbook includes key concepts at the foundation of the technology relevant for protein therapeutics including molecular biology, production and analysis procedures, formulation development, pharmacokinetics and pharmacodynamics, and immunogenicity, as well as chapters dealing with regulatory, economic, and pharmacy practice considerations.   The Fourth Edition brings an exciting and fundamental reorganization of the text, now structured into two sections: 1) an initial basic science and general features section; and 2) a section profiling the various therapeutic classes of biologics, including gene therapy.  Additionally, reorganization of the chapters examining the properties and applications of monoclonal antibodies, and oligonucleotides and siRNA has enhanced these important concepts in the text.  A completely new chapter has been added on cell-based technologies.   The Fourth Edition continues the popular self-assessment questions after each chapter to reinforce understanding of practical pharmaceutical applications, making this an indispensable text for self-study, the biopharmaceutical classroom, as well as for professional reference in practice or industry. .
650 0 _aMedicine.
650 0 _aPharmaceutical technology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmaceutical Sciences/Technology.
650 2 4 _aBiomedicine general.
700 1 _aCrommelin, Daan J. A.
_eeditor.
700 1 _aSindelar, Robert D.
_eeditor.
700 1 _aMeibohm, Bernd.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461464853
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-6486-0
912 _aZDB-2-SBL
942 _2Dewey Decimal Classification
_ceBooks
999 _c44645
_d44645