000			03113nam a22004817a 4500
001			sulb-eb0022570
003			BD-SySUS
005			20160413122307.0
007			cr nn 008mamaa
008			130405s2013 xxu| s |||| 0|eng d
020			_a9781461465492 _9978-1-4614-6549-2
024	7		_a10.1007/978-1-4614-6549-2 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
245	1	0	_aMolecular Genetics of Pancreatic Cancer _h[electronic resource] / _cedited by Diane M. Simeone, Anirban Maitra.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aV, 235 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aGenomic Alterations in Sporadic Pancreatic Cancer -- Molecular Pathology of Pancreatic Cancer Precursor Lesions -- Genetic Epidemiology and Pancreatic Cancer -- Translational Implications of Molecular genetics for Early Diagnosis of Pancreatic Cancer -- The Biology of K-Ras Signaling Pathways in Pancreatic Cancer -- Molecularly Targeted Therapies in Pancreatic Cancer -- Mouse Models of Pancreatic Cancer -- Genetics of Pancreatic Cancer Metastasis -- Epigenetic Alterations in Pancreatic Cancer -- New technologies in Molecular Characterization of Pancreatic Cancer -- Index.
520			_aPancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth. With new advances in molecular genetics in the field of pancreatic tumorigenesis, it is an opportune time to use these recent discoveries to enhance our understanding of pancreatic cancer biology and to improve outcomes in patients.  In this volume, leading experts in the field shed light on these findings describing the mutational landscape of pancreatic cancer, including new inroads into our understanding of familial pancreatic cancer, epidemiology, the biology of K-ras signaling, and the emerging contribution of epigenetic alterations to disease initiation and progression. The distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells is described, and implications of these interactions in the context of development of novel, personalized therapeutic options are explored.
650		0	_aMedicine.
650		0	_aCancer research.
650		0	_aHuman genetics.
650		0	_aCell biology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aCell Biology.
650	2	4	_aHuman Genetics.
700	1		_aSimeone, Diane M. _eeditor.
700	1		_aMaitra, Anirban. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461465485
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-6549-2
912			_aZDB-2-SBL
942			_2Dewey Decimal Classification _ceBooks
999			_c44662 _d44662