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003			BD-SySUS
005			20160413122307.0
007			cr nn 008mamaa
008			130403s2013 xxu| s |||| 0|eng d
020			_a9781461465584 _9978-1-4614-6558-4
024	7		_a10.1007/978-1-4614-6558-4 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
245	1	0	_aHuman Interphase Chromosomes _h[electronic resource] : _bBiomedical Aspects / _cedited by Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXVII, 216 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction. The view on human interphase chromosomes  in postgenomic era -- Interphase chromosome behavior in normal and diseased cells -- Nuclear architecture, chromosome domains and genetic damage -- Interphase chromosome of the human brain: the biological and clinical meaning of neural aneuploidy -- Differentiating chromosome fragmentation and premature chromosome condensation -- Chromosomes and nuclear organization in ICF Syndrome -- Interphase cytogenetics at the earliest stages of human development -- Organization of chromosomes in human sperm nucleus -- Interphase chromosome-specific multicolor banding -- Chromosome architecture studied by high resolution FISH-banding in three dimensionally preserved human interphase nuclei -- Technological solutions in human interphase cytogenetics -- Appendix: Molecular cytogenetics and interphase chromosomes on the internet -- Index.
520			_aThe beginning of interphase cytogenetics can be attributed to significant advances in human molecular genetics and cytogenetics. Owing to experimental and theoretical research at the interface between cellular and molecular levels of chromosomal organization and function, high-resolution techniques for chromosomal analysis (molecular cytogenetic techniques) have become available. Molecular cytogenetics is a branch of biomedical sciences that explores chromosomes at molecular and single-cell resolutions at all stages of the cell cycle. It also comprises the techniques that operate with either the entire genome or specific DNA sequences to analyze genomic structural and functional variations at chromosomal level. In postgenomic era, molecular cytogenetics has appreciably transformed and has given rise to a new field of genomics, called cytogenomics. As a result, new opportunities have emerged for analysis of human interphase chromosomes in almost all cell types and states at unprecedented resolution. In Human Interphase Chromosomes, the editors have provided an overview of current developments in the study of human interphase chromosomes with a special attention to available molecular cytogenetictechnologies for basic and clinical chromosome research.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aCytogenetics.
650		0	_aCell biology.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aCytogenetics.
650	2	4	_aCell Biology.
700	1		_aYurov, Yuri B. _eeditor.
700	1		_aVorsanova, Svetlana G. _eeditor.
700	1		_aIourov, Ivan Y. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461465577
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-6558-4
912			_aZDB-2-SBL
942			_2Dewey Decimal Classification _ceBooks
999			_c44665 _d44665