000 | 03084nam a22005057a 4500 | ||
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001 | sulb-eb0022767 | ||
003 | BD-SySUS | ||
005 | 20160413122317.0 | ||
007 | cr nn 008mamaa | ||
008 | 130622s2013 xxu| s |||| 0|eng d | ||
020 |
_a9781461473091 _9978-1-4614-7309-1 |
||
024 | 7 |
_a10.1007/978-1-4614-7309-1 _2doi |
|
050 | 4 | _aRB155-155.8 | |
050 | 4 | _aQH431 | |
072 | 7 |
_aMFN _2bicssc |
|
072 | 7 |
_aMED107000 _2bisacsh |
|
082 | 0 | 4 |
_a611.01816 _223 |
082 | 0 | 4 |
_a599.935 _223 |
245 | 1 | 0 |
_aGenetic Variants in Alzheimer's Disease _h[electronic resource] / _cedited by Kevin Morgan, Minerva M. Carrasquillo. |
264 | 1 |
_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013. |
|
300 |
_aVIII, 254 p. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
||
337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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505 | 0 | _aThe Genetics of Alzheimer’s disease: Introduction and Perspective for the Future -- Apolipoprotein E -- Clusterin -- PICALM -- Complement Component (3b/4b) Receptor 1(CR1) -- Bridging Integrator 1 (BIN1) -- ATP-binding cassette, sub-family A (ABC1), member 7 (ABCA7) -- Membrane-spanning 4-domains subfamily A, MS4A cluster -- Sialic acid binding immunoglobulin-like lectin-3 (CD33) -- Erythropoietin-producing human hepatocellular carcinoma (EphA1) -- CD2-associated protein (CD2AP) -- Other Genes Implicated in Alzheimer’s Disease -- The Future Role of Biomarkers in Alzheimer’s Disease Diagnostics -- Index. | |
520 | _aSince 2009, a revolution has been witnessed in Alzheimer’s Disease genetics. New genetic links are being discovered at an unprecedented pace and our understanding of the molecular mechanisms of neurodegeneration have taken a quantum leap forward. This book provides a thorough description of the genes that have been implicated in the aetiology of late-onset Alzheimer’s disease (LOAD) based on evidence of genetic association. These “AD susceptibility genes” are described both in their genomic and cellular context, as well as with respect to their known or suspected molecular functions. Although these genes are not sufficient to explain all of the genetic contributions to LOAD, they represent the best replicated set of genes to date. Undoubtedly the list will grow as more advanced genomic approaches towards the identification of novel LOAD genes progresses. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aHuman genetics. | |
650 | 0 | _aMedical genetics. | |
650 | 0 | _aNeurosciences. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aHuman Genetics. |
650 | 2 | 4 | _aNeurosciences. |
650 | 2 | 4 | _aGene Function. |
700 | 1 |
_aMorgan, Kevin. _eeditor. |
|
700 | 1 |
_aCarrasquillo, Minerva M. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781461473084 |
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4614-7309-1 |
912 | _aZDB-2-SBL | ||
942 |
_2Dewey Decimal Classification _ceBooks |
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999 |
_c44859 _d44859 |