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003			BD-SySUS
005			20160413122323.0
007			cr nn 008mamaa
008			130813s2013 xxu| s |||| 0|eng d
020			_a9781461479697 _9978-1-4614-7969-7
024	7		_a10.1007/978-1-4614-7969-7 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
245	1	0	_aStearoyl-CoA Desaturase Genes in Lipid Metabolism _h[electronic resource] / _cedited by James M. Ntambi, Ph.D.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXI, 239 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aSCD genes of fatty acid synthesis -- SCD genes in heart metabolism -- SCD genes in liver metabolism -- SCD genes in harderian and perpetual glands -- SCD genes In lipogenesis -- SCD genes lipoproteins -- SCD genes in WAT -- SCD genes in muscle -- SCD genes in the brain -- SCD genes in inflammation -- SCD genes in ER Stress -- SCD genes in skin -- SCD genes in insulin signaling -- SCD genes in thermogenesis -- SCD genes in diabetes -- SCD genes atherosclerosis -- SCD genes in Adipocyte differentiation -- SCD genes and epigenetics -- SCD genes in fatty liver disease -- SCD genes in Colitis -- SCD genes in leptin signaling.
520			_aJames Ntambi has gathered top authors to write about the remarkable growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species including human. The book shows that beginning with simple cellular models of differentiation a broad and comprehensive analysis of the SCD gene family in a number of species and biological systems has been carried out over the course of the last twenty five years. SCD is a central enzyme in lipid metabolism that synthesizes monounsaturated fatty acids (MUFA) from saturated fatty acid precursors. At first glance, SCD would be considered a housekeeping enzyme because its product oleate is a well-known MUFA that is abundant in many dietary sources and tissue lipids. A particular highlight in the chapters of the book is that MUFAs may have signaling properties that regulate metabolism. For example, a proper ratio of saturated to MUFA contributes to membrane fluidity, and oleate has also been implicated as a mediator of signal transduction, cellular differentiation and metabolic homeostasis. It is also highlighted that SCD-1 repression mediates the metabolic effects of the hormone leptin. Conditional alleles and corresponding tissue-specific knockout mouse models for many of the SCD gene isorfms have provided a wealth of information on not only tissue-specific fatty acid metabolism but also the key transcription factors that regulate SCD expression under a variety of metabolic and genetic backgrounds. The studies described indicate that control of SCD expression occurs via a series of complex signal transduction schemes making SCD one of the most highly studied lipogenic gene families to date.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aEndocrinology.
650		0	_aLipids.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aEndocrinology.
650	2	4	_aLipidology.
700	1		_aNtambi, Ph.D., James M. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461479680
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-7969-7
912			_aZDB-2-SBL
942			_2Dewey Decimal Classification _ceBooks
999			_c44975 _d44975