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008 131002s2013 xxu| s |||| 0|eng d
020 _a9781461484127
_9978-1-4614-8412-7
024 7 _a10.1007/978-1-4614-8412-7
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aMolecular Pathogenesis of Colorectal Cancer
_h[electronic resource] /
_cedited by Kevin M. Haigis, Ph.D.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aVIII, 316 p. 30 illus., 29 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- The Genetics of Colorectal Cancer -- Molecular Mechanisms of Colorectal Carcinogenesis -- The association between inflammation and colorectal cancer -- Importance of the niche: Wnt signalling and Stem cell plasticity in intestinal homeostasis and disease -- Mutational activation of KRAS and BRAF in colorectal cancer -- The PI3K pathway in Colorectal Cancers -- TGF-ß signaling pathway and colorectal cancer -- The Clinical Significance of Mutations in Colorectal Cancer -- Colorectal Cancer Genome and Its Implications -- Copy-Number Alterations in the Colorectal Cancer Genome -- Genome-wide association studies in colorectal cancer -- Future prospects for leveraging molecular information in the fight against colorectal cancer -- Index.
520 _aFor more than two decades, colorectal cancer has served as the paradigm for the cooperative activity of oncogenes and tumor suppressor genes in cancer initiation and progression. The depth of molecular characterization for this disease is unparalleled, with specific mutations correlated to each histologic stage of progression from normal colon to malignant colorectal cancer. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. This book explores the past, present, and future of colorectal cancer genetics, with particular emphasis on how knowledge of the molecular pathogenesis of the disease leads to the development of novel therapeutic strategies. Individual chapters discuss general topics, such as genomic instability and inflammation, or else specific pathways, for example RAS, PI3K, and TGF-b, that play a role in colorectal cancer progression.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aMolecular biology.
650 0 _aProteins.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aMolecular Medicine.
650 2 4 _aProtein Science.
650 2 4 _aCell Biology.
700 1 _aHaigis, Ph.D., Kevin M.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461484110
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-8412-7
912 _aZDB-2-SBL
942 _2Dewey Decimal Classification
_ceBooks
999 _c45016
_d45016