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020 _a9781461485483
_9978-1-4614-8548-3
024 7 _a10.1007/978-1-4614-8548-3
_2doi
050 4 _aQH324
072 7 _aPS
_2bicssc
072 7 _aPDN
_2bicssc
072 7 _aSCI008000
_2bisacsh
072 7 _aSCI043000
_2bisacsh
082 0 4 _a570.28
_223
245 1 0 _aMolecular Biophysics for the Life Sciences
_h[electronic resource] /
_cedited by Norma Allewell, Linda O. Narhi, Ivan Rayment.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXII, 397 p. 132 illus., 70 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBiophysics for the Life Sciences ;
_v6
520 _aThis volume of the series Biophysics for the Life Sciences focuses on the conceptual framework and major research tools of contemporary molecular biophysics.  It is designed to enable non-specialists—both students and professionals in other fields—to understand how these approaches can be used across the biosciences and in medicine, agriculture, biotechnology, pharmaceutical development and other fields.  The scope of this volume is appropriate for advanced undergraduate and graduate courses in biophysics and biophysical chemistry.   The book begins with an overview of the development of molecular biophysics and a brief survey of  structural, physical, and chemical principles.  Subsequent chapters written by experts present, with examples, the major experimental methods: optical spectroscopy, X-ray and neutron diffraction and scattering, nuclear magnetic resonance, electron paramagnetic resonance, mass spectrometry, and single molecule methods.  The relationship between the biophysical properties of biological macromolecules and their roles as molecular machines is emphasized throughout and illustrated with three examples—DNA helicases, rotary motor ATPases, and myosin.  The concluding chapter discusses future prospects in X-ray and neutron scattering, mass spectrometry, and pharmaceutical development.    Dr. Norma M. Allewell is Professor of Cell Biology and Molecular Genetics and Affiliate Professor of Chemistry and Biochemistry at the University of Maryland, where she served as Dean of the College of Chemical and Life Sciences for a decade. Her research focuses on protein structure, function and dynamics, and metabolic regulatory mechanisms and diseases.   Dr. Linda Narhi is a Scientific Executive Director in the Product Attribute Science Group at Amgen, where her responsibilities include solution stability assessment of all protein-based therapeutic candidates, and developing and implementing predictive assays for protein stability to process, storage, and delivery conditions.   Dr. Ivan Rayment is Professor of Biochemistry at the University of Wisconsin-Madison, where he holds the Michael G. Rossmann Professorship in Biochemistry. He has a wide range of interests in structural biology and has made seminal contributions to our understanding of the structural basis of motility, enzyme evolution, cobalamin biosynthesis, and transposition.
650 0 _aLife sciences.
650 0 _aPharmaceutical technology.
650 0 _aBiotechnology.
650 0 _aBiology
_xTechnique.
650 0 _aBiophysics.
650 0 _aBiological physics.
650 0 _aSpectroscopy.
650 0 _aMicroscopy.
650 1 4 _aLife Sciences.
650 2 4 _aBiological Techniques.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aBiotechnology.
650 2 4 _aSpectroscopy and Microscopy.
650 2 4 _aPharmaceutical Sciences/Technology.
700 1 _aAllewell, Norma.
_eeditor.
700 1 _aNarhi, Linda O.
_eeditor.
700 1 _aRayment, Ivan.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461485476
830 0 _aBiophysics for the Life Sciences ;
_v6
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-8548-3
912 _aZDB-2-SBL
942 _2Dewey Decimal Classification
_ceBooks
999 _c45031
_d45031