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008 140123s2013 xxu| s |||| 0|eng d
020 _a9781461490449
_9978-1-4614-9044-9
024 7 _a10.1007/978-1-4614-9044-9
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
245 1 4 _aThe Toxicant Induction of Irritant Asthma, Rhinitis, and Related Conditions
_h[electronic resource] /
_cedited by William J. Meggs.
264 1 _aBoston, MA :
_bSpringer US :
_bImprint: Springer,
_c2013.
300 _aVI, 294 p. 24 illus., 18 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction: Irritant asthma, irritant rhinitis -- Airway Anatomy, Physiology, and Inflammation -- Reactive Airways Dysfunction Syndrome (RADS) and Irritant-Induced Asthma -- Acute Toxicity of Respiratory Irritant Exposures -- Particulate Exposure and Cardiovascular Inflammation -- Products of Combustion -- Irritant and Airborne Contact Dermatitis -- Exposure Limits -- Occupational Issues Related to Respiratory Irritants -- The Brain as a Target Organ for Allergic and Irritant Sensitivity: A Review and Suggestions for Research -- An Approach to Treating Irritant Airway Inflammation -- Summary and Research Needs -- Index.
520 _aUntoward reactions to environmental chemicals, particularly when a subject reports difficulties with exposures to chemicals of diverse classes involving more than one organ system, have been poorly understood and an area of great controversy. Studies of airway inflammation induced by respiratory irritants have established neurogenic inflammation as the mechanism for irritant asthma and rhinitis. Remodeling of the airway after an acute irritant exposure can lead to a heightened sensitivity to irritants that persists. Recognition that rhinitis, while sometimes regarded as a trivial disease, is associated with extra-airway manifestations such as fatigue and disturbances of sleep, mood, and cognition, further elucidates how chemical exposures can be serious for susceptible individuals. This book reviews current scientific understanding of irritant airway inflammation and related conditions, including cardiovascular effects of particulate exposures, airborne contact dermatitis and irritant dermatitis, and the brain as a target organ for both allergic and irritant reactions. It is essential reading for physicians and other healthcare workers caring for patients with environmental intolerances.  Allergists, toxicologists, occupational and environmental physicians, and pulmonologists will find the materials particularly valuable. Patients and advocates for those with chemical intolerances will also find the book of interest.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aPharmacology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aMedicine/Public Health, general.
650 2 4 _aImmunology.
700 1 _aMeggs, William J.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461490432
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-9044-9
912 _aZDB-2-SBL
942 _2Dewey Decimal Classification
_ceBooks
999 _c45068
_d45068