000			03438nam a22005057a 4500
001			sulb-eb0023049
003			BD-SySUS
005			20160413122332.0
007			cr nn 008mamaa
008			120928s2013 xxu| s |||| 0|eng d
020			_a9781627031011 _9978-1-62703-101-1
024	7		_a10.1007/978-1-62703-101-1 _2doi
050		4	_aQH588.S83
072		7	_aPSAK _2bicssc
072		7	_aSCI017000 _2bisacsh
072		7	_aSCI049000 _2bisacsh
082	0	4	_a571.6 _223
245	1	0	_aMitochondrial DNA, Mitochondria, Disease and Stem Cells _h[electronic resource] / _cedited by Justin C. St. John.
264		1	_aTotowa, NJ : _bHumana Press : _bImprint: Humana Press, _c2013.
300			_aX, 190 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aStem Cell Biology and Regenerative Medicine
505	0		_aClinical Approach to the Diagnosis of Mitochondrial Disease -- Mitochondrial DNA Mutations and Their Effects on Complex I Biogenesis: Implications for Metabolic Disease -- Embryonic Stem Cells: A Signalling Perspective -- From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) A Mitochondrial Odyssey -- From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases -- The Role of Mitochondrial DNA in Tumor Cells -- Assisted Reproductive Technologies to Prevent the Transmission of mtDNA from one Generation to the Next.
520			_aThis volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.
650		0	_aLife sciences.
650		0	_aCell biology.
650		0	_aStem cells.
650		0	_aCell physiology.
650	1	4	_aLife Sciences.
650	2	4	_aStem Cells.
650	2	4	_aCell Biology.
650	2	4	_aCell Physiology.
700	1		_aSt. John, Justin C. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781627031004
830		0	_aStem Cell Biology and Regenerative Medicine
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-62703-101-1
912			_aZDB-2-SBL
942			_2Dewey Decimal Classification _ceBooks
999			_c45141 _d45141