| 000 | 03040nam a22005057a 4500 | ||
|---|---|---|---|
| 001 | sulb-eb0023162 | ||
| 003 | BD-SySUS | ||
| 005 | 20160413122337.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 130709s2013 sz | s |||| 0|eng d | ||
| 020 |
_a9783034806824 _9978-3-0348-0682-4 |
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| 024 | 7 |
_a10.1007/978-3-0348-0682-4 _2doi |
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| 050 | 4 | _aQD431-431.7 | |
| 072 | 7 |
_aPSBZ _2bicssc |
|
| 072 | 7 |
_aSCI007000 _2bisacsh |
|
| 082 | 0 | 4 |
_a572.6 _223 |
| 100 | 1 |
_aCastellano, Immacolata. _eauthor. |
|
| 245 | 1 | 0 |
_aGamma-Glutamyl Transpeptidases _h[electronic resource] : _bStructure and Function / _cby Immacolata Castellano, Antonello Merlino. |
| 264 | 1 |
_aBasel : _bSpringer Basel : _bImprint: Springer, _c2013. |
|
| 300 |
_aVIII, 57 p. 28 illus., 18 illus. in color. _bonline resource. |
||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
||
| 490 | 1 |
_aSpringerBriefs in Biochemistry and Molecular Biology, _x2211-9353 |
|
| 505 | 0 | _a 1 Introduction -- 2 Occurrence, genes and gene expression -- 3 Structure and function of γ-GTs -- 4 Autoprocessing and reaction mechanism of γ-GTs -- 5 γ-GT in bioclinical -- 6 γ-GTs: biotechnological and biomedical applications -- 7 Conclusions -- References. | |
| 520 | _a Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine. | ||
| 650 | 0 | _aLife sciences. | |
| 650 | 0 | _aHuman physiology. | |
| 650 | 0 | _aBiochemical engineering. | |
| 650 | 0 | _aEnzymology. | |
| 650 | 1 | 4 | _aLife Sciences. |
| 650 | 2 | 4 | _aEnzymology. |
| 650 | 2 | 4 | _aHuman Physiology. |
| 650 | 2 | 4 | _aBiochemical Engineering. |
| 700 | 1 |
_aMerlino, Antonello. _eauthor. |
|
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783034806817 |
| 830 | 0 |
_aSpringerBriefs in Biochemistry and Molecular Biology, _x2211-9353 |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-0348-0682-4 |
| 912 | _aZDB-2-SBL | ||
| 942 |
_2Dewey Decimal Classification _ceBooks |
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| 999 |
_c45254 _d45254 |
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