000 03079nam a22004937a 4500
001 sulb-eb0023302
003 BD-SySUS
005 20160413122344.0
007 cr nn 008mamaa
008 130711s2013 gw | s |||| 0|eng d
020 _a9783319007083
_9978-3-319-00708-3
024 7 _a10.1007/978-3-319-00708-3
_2doi
050 4 _aQD450-882
072 7 _aPNR
_2bicssc
072 7 _aSCI013050
_2bisacsh
082 0 4 _a541
_223
100 1 _aLau, Janet T F.
_eauthor.
245 1 0 _aTowards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers
_h[electronic resource] /
_cby Janet T F Lau.
264 1 _aHeidelberg :
_bSpringer International Publishing :
_bImprint: Springer,
_c2013.
300 _aXXII, 180 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
505 0 _aA Zinc(II) Phthalocyanine Conjugated with an Oxaliplatin Derivative for Dual Chemo- and Photodynamic Therapy -- Zinc(II) Phthalocyanine-Polyamine Conjugates as Efficient Photosensitizers for Photodynamic Therapy -- A Redox-Responsive Silicon(IV) Phthalocyanine for Targeted Photodynamic Therapy -- A Dual pH- and Redox-Responsive Phthalocyanine-Based Photosensitizer for Targeted Photodynamic Therapy.
520 _aJanet Lau's thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but can still be removed under a tumor-associated environment such as low pH and high thiol concentration. This thesis reports dual activatable photosensitizers for the first time. Overall the studies included are original and the effects have been well demonstrated at the cellular level. The work in this thesis is of much current interest and importance, and can pave foundation for further developments. Accordingly, parts of the results have been published in prestigious scientific journals.
650 0 _aChemistry.
650 0 _aCancer research.
650 0 _aPhysical chemistry.
650 0 _aMedicinal chemistry.
650 1 4 _aChemistry.
650 2 4 _aPhysical Chemistry.
650 2 4 _aMedicinal Chemistry.
650 2 4 _aCancer Research.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319007076
830 0 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-00708-3
912 _aZDB-2-CMS
942 _2Dewey Decimal Classification
_ceBooks
999 _c45394
_d45394