000			03865nam a22004817a 4500
001			sulb-eb0023528
003			BD-SySUS
005			20160413122356.0
007			cr nn 008mamaa
008			140131s2013 gw | s |||| 0|eng d
020			_a9783319042411 _9978-3-319-04241-1
024	7		_a10.1007/978-3-319-04241-1 _2doi
050		4	_aQR1-502
072		7	_aPSG _2bicssc
072		7	_aSCI045000 _2bisacsh
082	0	4	_a579 _223
100	1		_aRosenberg, Eugene. _eauthor.
245	1	4	_aThe Hologenome Concept: Human, Animal and Plant Microbiota _h[electronic resource] / _cby Eugene Rosenberg, Ilana Zilber-Rosenberg.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2013.
300			_aXIII, 178 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction: Symbioses and the Hologenome Concept -- Origin of Prokaryotes and Eukaryotes -- Abundance and Diversity of Microbiota -- Microbiotas are Transmitted between Holobiont Generations -- Microbiotas are Part of Holobiont Fitness -- Variation in Holobionts -- Viruses are part of the Holobiont`s Fitness and Evolution -- Evolution of Holobionts -- Pathogens as Symbionts -- Prebiotics, Probiotics, Synbiotics and Phage Therapy -- Epilogue.
520			_aGroundbreaking research over the last 10 years has given rise to the hologenome concept of evolution. This concept posits that the holobiont (host plus all of its associated microorganisms) and its hologenome (sum of the genetic information of the host and its symbiotic microorganisms), acting in concert, function as a unique biological entity and therefore as a level of selection in evolution. All animals and plants harbor abundant and diverse microbiota, including viruses. Often the amount of symbiotic microorganisms and their combined genetic information far exceed that of their host. The microbiota with its microbiome, together with the host genome, can be transmitted from one generation to the next and thus propagate the unique properties of the holobiont. The microbial symbionts and the host interact in a cooperative way that affects the health of the holobiont within its environment. Beneficial microbiota protects against pathogens, provides essential nutrients, catabolizes complex polysaccharides, renders harmful chemicals inert, and contributes to the performance of the immune system. In humans and animals, the microbiota also plays a role in behavior. The sum of these cooperative interactions characterizes the holobiont as a unique biological entity. Genetic variation in the hologenome can be brought about by changes in either the host genome or the microbial population genomes (microbiome). Evolution by cooperation can occur by amplifying existing microbes, gaining novel microbiota and by acquiring microbial and viral genes. Under environmental stress, the microbiome can change more rapidly and in response to more processes than the host organism alone and thus influences the evolution of the holobiont. Prebiotics, probiotics, synbiotics and phage therapy are discussed as applied aspects of the hologenome concept.
650		0	_aLife sciences.
650		0	_aEvolutionary biology.
650		0	_aMicrobiology.
650		0	_aZoology.
650	1	4	_aLife Sciences.
650	2	4	_aMicrobiology.
650	2	4	_aEvolutionary Biology.
650	2	4	_aZoology.
700	1		_aZilber-Rosenberg, Ilana. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319042404
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-319-04241-1
912			_aZDB-2-SBL
942			_2Dewey Decimal Classification _ceBooks
999			_c45620 _d45620