000			03294nam a22005057a 4500
001			sulb-eb0023677
003			BD-SySUS
005			20160413122402.0
007			cr nn 008mamaa
008			121212s2013 gw | s |||| 0|eng d
020			_a9783642279287 _9978-3-642-27928-7
024	7		_a10.1007/978-3-642-27928-7 _2doi
050		4	_aRC321-580
072		7	_aPSAN _2bicssc
072		7	_aMED057000 _2bisacsh
082	0	4	_a612.8 _223
245	1	0	_aProtein Quality Control in Neurodegenerative Diseases _h[electronic resource] / _cedited by Richard I. Morimoto, Yves Christen.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2013.
300			_aXII, 136 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aResearch and Perspectives in Alzheimer's Disease, _x0945-6066
505	0		_aThe Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto -- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegeneration by David Ron -- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin -- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen -- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo -- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima -- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl -- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner -- Therapeutic Potential of Longevity Modulators as Neuroprotective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri -- Subject code.
520			_aThe health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
650		0	_aMedicine.
650		0	_aMolecular biology.
650		0	_aNeurosciences.
650		0	_aNeurochemistry.
650	1	4	_aBiomedicine.
650	2	4	_aNeurosciences.
650	2	4	_aNeurochemistry.
650	2	4	_aMolecular Medicine.
700	1		_aMorimoto, Richard I. _eeditor.
700	1		_aChristen, Yves. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642279270
830		0	_aResearch and Perspectives in Alzheimer's Disease, _x0945-6066
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-27928-7
912			_aZDB-2-SBL
942			_2Dewey Decimal Classification _ceBooks
999			_c45769 _d45769