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008 121026s2013 gw | s |||| 0|eng d
020 _a9783642332531
_9978-3-642-33253-1
024 7 _a10.1007/978-3-642-33253-1
_2doi
050 4 _aQR1-502
072 7 _aPSG
_2bicssc
072 7 _aSCI045000
_2bisacsh
082 0 4 _a579
_223
245 1 0 _aProkaryotic Toxin-Antitoxins
_h[electronic resource] /
_cedited by Kenn Gerdes.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aVIII, 368 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction -- Type I Toxin – Antitoxin Systems: Hok/Sok and Fst -- Novel Type I Toxin – Antitoxin Systems -- Type II TA Loci: The Ccdab and Parde Families -- Type II TA Loci: The Relbe Family -- Type II TA Loci: The Unusual Mqsra Locus -- Type II TA Loci: The Mazef Family -- Type II TA Loci: Vapbc and Other TA Loci In Mycobacteria -- Type II TA Loci: Phd Doc Family -- Type II TA Loci: The Fic Family -- Type II TA Loci, Hipab And Persisters -- Type II TA Loci: Zeta/Pezt Family -- Type II Loci: Phylogeny -- Type III TA Loci -- TA Loci Encoded By Plasmids -- TA Loci in Archaea -- TA Loci in Mycobacterium Tuberculosis -- TA Loci in Streptococcus Pneumoniae -- Biotechnological and Medical Exploitations Of TA Genes and Their Components.
520 _aProkaryotic Toxins – Antitoxins presents the first comprehensive overview of an exciting and rapidly expanding research field. Toxin – antitoxin (TA) genes were first identified on plasmids almost 30 years ago. Since then it has become evident that TA genes are highly abundant on both plasmids and chromosomes belonging to the bacterial and archaeal domains. TA genes come in three variants, depending on how the antitoxin works. In the most common TA genes, called type II TA loci, the antitoxins are proteins that combine with and neutralize the toxins. Even though the toxins come from at least 10 evolutionary independent gene families they inhibit translation and induce dormancy and persistence. The toxins inhibit translation using different molecular mechanisms. For example, the most common toxin family, called VapC (Virulence-associated protein), inhibits translation by cleaving initiator tRNA. Another common toxin family, called RelE, inhibits translation by cleaving messenger RNA  positioned at the ribosome. Recent database mining revealed more than 10,000 such TA loci in »700 prokaryotic organisms. Remarkably, in some species, TA genes have undergone dramatic expansions. For example, the highly persistent major human pathogen Mycobacterium tuberculosis has almost 100 TA loci belonging to different gene families, whereas its close relative M. leprae has none. All sequenced archaeal genomes to date have at least two TA loci and the thermophilic archaeon Sulfolobus tokodaii has »40 TA loci. The considerable expansion of the TA genes is a biological mystery but may be related to the biological function(s) of TA genes, a topic that is still hotly debated. The genetic analysis of TA genes is hampered by the multitude of seemingly similar genes within one particular genome. However, recent analysis with the model organism E. coli revealed a breakthrough indicating that TA genes contribute cumulatively to bacterial persistence. All known free-living bacteria that form persisters, cells that survive antibiotics and other environmental threats, contain TA genes. Together, these groundbreaking observations have raised the exciting possibility that TA genes are involved in the persistence of many bacteria, including major human pathogens such as M. tuberculosis. The expanding TA field has an exciting future ahead of it.
650 0 _aLife sciences.
650 0 _aMedical microbiology.
650 0 _aMicrobiology.
650 0 _aApoptosis.
650 0 _aMicrobial genetics.
650 0 _aMicrobial genomics.
650 1 4 _aLife Sciences.
650 2 4 _aMicrobiology.
650 2 4 _aMicrobial Genetics and Genomics.
650 2 4 _aMedical Microbiology.
650 2 4 _aApoptosis.
650 2 4 _aApplied Microbiology.
700 1 _aGerdes, Kenn.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642332524
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-33253-1
912 _aZDB-2-SBL
942 _2Dewey Decimal Classification
_ceBooks
999 _c46290
_d46290