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020 _a9783642366482
_9978-3-642-36648-2
024 7 _a10.1007/978-3-642-36648-2
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
245 1 0 _aProgrammed Cells from Basic Neuroscience to Therapy
_h[electronic resource] /
_cedited by Fred H. Gage, Yves Christen.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aXII, 130 p. 14 illus., 13 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aResearch and Perspectives in Neurosciences,
_x0945-6082 ;
_v20
505 0 _aNuclear reprogramming by eggs and oocytes and eventual prospects of cell replacement therapy.- iPS technology and disease research: issues to be resolved -- ES and iPS cells as tools for modeling human aging .-Characterizing neural circuitry with programmed human neurons.- Direct conversion of fibroblasts to neuronal cells -- Human pluripotent stem cells as tools for modelling neurodegeneration.- From Rett syndrome to classical autism: modeling autism spectrum disorders using human neurons.- Testing evolutionary principles in a dish using embryonic stem cells: the example of the Huntington's Disease gene.- Using stem cells to discover therapeutic targets in ALS and SMA .- Using stem cells to understand and treat Alzheimer's disease.- Using pluripotent stem cells to decipher mechanisms and identify treatments for diseases that affect the brain.- Modeling neural development and disease in human pluripotent stem cells -- Subject index.
520 _aThe recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed the experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. In addition, because PSC technology allows for the study of human neurons during development, disease-specific pathways can be investigated prior to and during disease onset. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, it is now feasible to obtain gene expression profiles from neurons that capture the genetic uniqueness of each patient. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aNeurology.
650 0 _aStem cells.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aStem Cells.
650 2 4 _aNeurology.
700 1 _aGage, Fred H.
_eeditor.
700 1 _aChristen, Yves.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642366475
830 0 _aResearch and Perspectives in Neurosciences,
_x0945-6082 ;
_v20
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-36648-2
912 _aZDB-2-SBL
942 _2Dewey Decimal Classification
_ceBooks
999 _c46861
_d46861