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008 130913s2013 gw | s |||| 0|eng d
020 _a9783642394263
_9978-3-642-39426-3
024 7 _a10.1007/978-3-642-39426-3
_2doi
050 4 _aQD431-431.7
072 7 _aPSBC
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572.6
_223
245 1 0 _aTranslation in Mitochondria and Other Organelles
_h[electronic resource] /
_cedited by Anne-Marie Duchêne.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aVI, 265 p. 44 illus., 36 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aStructural aspects of mitochondrial ribosome function -- Mechanism and control of protein synthesis in mammalian mitochondria -- Translation in mammalian mitochondria : Order and disorder linked to tRNA and Aminoacyl-tRNA synthetases -- Mitochondrial targeting of RNA and mitochondrial translation in yeast and mammalians -- Mechanisms and control of protein synthesis in yeast mitochondria -- Mitochondrial translation in trypanosomatids -- Translation in mitochondria and apicoplasts in Apicomplexa -- Translation in mitochondria in green alga and higher plants -- Translation in flowering plant chloroplasts -- The chloroplasts as platform for recombinant proteins production.
520 _aThe present book gives an overview on the similarities and differences of the various translation systems. Moreover, it highlights the mechanisms and control of translation in mitochondria and other organelles such as plastids and apicoplasts in different organisms. Lastly, it offers an outlook on future developments and applications that might be made possible by a better understanding of translation in mitochondria and other organelles.  Mitochondria and plastids originate from the endosymbiosis of bacteria. Over the course of evolution, most of the bacterial genes have been lost or transferred to the nuclear genome. Present-day mitochondria and plastids retain only a vestige of the genome of the ancestral bacteria, but the few organellar-encoded protein genes remain essential and must be translated. Organellar translation machineries present clear specificities compared to cytosolic translation machineries, but also from one organism to the other. The organellar translation machineries appear to consist of organellar-encoded and nucleus-encoded components. They rely on crosstalk between genomes and are predominantly controlled by specific mechanisms. Organellar ribosomes show clear differences compared to the ancestral bacterial ribosomes or to the cytosolic ones. Moreover, transfer RNAs and aminoacyl-tRNA synthetases are key components of protein-synthesizing systems, and a full set of both types of macromolecules is required in each compartment where translation occurs. Organellar translations are increasingly becoming a subject of investigation. Translation dysfunctions in human mitochondria are responsible for numerous diseases, and organellar translation systems in some parasites offer potential targets for drug development. Lastly, chloroplasts can be used as platforms for the production of recombinant proteins.
650 0 _aLife sciences.
650 0 _aCytogenetics.
650 0 _aProteins.
650 0 _aCell biology.
650 0 _aEvolutionary biology.
650 1 4 _aLife Sciences.
650 2 4 _aProtein Science.
650 2 4 _aCell Biology.
650 2 4 _aCytogenetics.
650 2 4 _aEvolutionary Biology.
700 1 _aDuchêne, Anne-Marie.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642394256
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-39426-3
912 _aZDB-2-SBL
942 _2Dewey Decimal Classification
_ceBooks
999 _c47406
_d47406