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003			BD-SySUS
005			20160413122547.0
007			cr nn 008mamaa
008			120903s2013 au | s |||| 0|eng d
020			_a9783709111253 _9978-3-7091-1125-3
024	7		_a10.1007/978-3-7091-1125-3 _2doi
050		4	_aRC109-216
072		7	_aMJCJ _2bicssc
072		7	_aMED022090 _2bisacsh
082	0	4	_a616.9 _223
245	1	0	_aDrug Resistance in Leishmania Parasites _h[electronic resource] : _bConsequences, Molecular Mechanisms and Possible Treatments / _cedited by Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves.
264		1	_aVienna : _bSpringer Vienna : _bImprint: Springer, _c2013.
300			_aXIV, 462 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aForeword -- Introduction. Leishmaniasis, the biology of a parasite. Alicia Ponte Sucre -- I Determinant features in leishmaniasis -- 1 Molecular evolution and phylogeny of Leishmania. Gabriele Schoenian, Elisa Cupolillo, Isabel Mauricio -- 2 The role of reservoirs: Canine leishmaniasis. Lenea Campino, Carla Maia -- 3 Epidemiology of leishmaniasis in the time of drug resistance. Jean Claude Dujardin, Saskya Decuypere -- II Leishmania and the immune system -- 4 The role of the immune system in resistance to infection. Lukasz Kedzierski, Krystal J. Evans -- 5 Vaccination as a control measure. Katrin Färber , Heidrun Moll -- 6 Leishmania vaccines: Past, Present and Future. Bhavana Sethu Lakshmi, Rentala Madhubala -- III Challenges in the diagnosis, treatment and control of leishmaniasis in times of drug resistance -- 7 Co-infection with HIV. Margriet den Boer, Luis Rivas, Jorge Alvar -- 8 Visceral leishmaniasis. Shyam Sundar , J aya Chakravarty -- 9 American Tegumentary leishmaniasis. Olga Zerpa, Alicia Ponte-Sucre -- IV Molecular features of drug-resistant Leishmania -- 10 Genetic expression and drug resistance, the role of proteomics. Patricia Cuervo, Jose Batista de Jesus -- 11 The role of ABC transporters in drug-resistant Leishmania. Adriano C Coelho, Paulo C Cotrim -- 12 Functional analysis of Leishmania membrane (non ABC) transporters involved in drug resistance. Scott M Landfear -- 13 Intracellular mechanisms of resistance in Leishmania -- V Pharmacology and chemotherapy of leishmaniasis. Mitali Chatterjee -- 14 Classical vs new Treatment regimens. Louis Maes, Raquel Andreia Inocencio da Luz, Paul Cos, Vanessa Yardley -- 15 Drug targets, drug effectors and drug targeting and delivery. Philippe M Loiseau, Gillian Barratt -- 16 Mechanisms of miltefosine resistance in Leishmania. Francisco Gamarro, María P Sánchez-Cañete, Santiago Castanys -- 17 P-glycoprotein-like transporters in Leishmania: a search for reversal agents. Bruno Pradines -- VI Strategies to circumvent drug resistance in Leishmania -- 18 The relevance of susceptibility tests, breakpoints and markers. Louis Maes, Paul Cos and Simon Croft -- 19 The Concept of Fitness and drug resistance in Leishmania. Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves.
520			_aOne of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.
650		0	_aMedicine.
650		0	_aVaccines.
650		0	_aDrug resistance.
650		0	_aParasitology.
650		0	_aPharmaceutical technology.
650		0	_aInfectious diseases.
650		0	_aMicrobiology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aInfectious Diseases.
650	2	4	_aDrug Resistance.
650	2	4	_aPharmaceutical Sciences/Technology.
650	2	4	_aVaccine.
650	2	4	_aParasitology.
650	2	4	_aMicrobiology.
700	1		_aPonte-Sucre, Alicia. _eeditor.
700	1		_aDiaz, Emilia. _eeditor.
700	1		_aPadrón-Nieves, Maritza. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783709102381
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-7091-1125-3
912			_aZDB-2-SME
942			_2Dewey Decimal Classification _ceBooks
999			_c47914 _d47914