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008			120814s2013 ne | s |||| 0|eng d
020			_a9789400746947 _9978-94-007-4694-7
024	7		_a10.1007/978-94-007-4694-7 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
245	1	0	_aTumor Ablation _h[electronic resource] : _bEffects on Systemic and Local Anti-Tumor Immunity and on Other Tumor-Microenvironment Interactions / _cedited by Yona Keisari.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013.
300			_aXII, 156 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aThe Tumor Microenvironment ; _v5
520			_aThe growing knowledge on tumor-immune response interactions and on the tumor microenvironment did not translate so far into better control of cancer by anti-tumor vaccination. The percentage of patients who benefited from vaccination strategies is still too small to justify their general use. It is the aim of this book to present an alternative to the conventional approach of developing injected tumor vaccines to activate anti-tumor immunity, which will fight cancer. It is argued that in situ tumor ablation (destruction) that involves tumor antigen release; cross presentation and the release of danger associated molecular patterns (DAMPs) can make the tumor its own cellular vaccine. Tumor ablation methods using chemicals, radiation, photodynamic therapy, cryoablation, high-temperature, radiofrequency, high intensity focused ultrasound, and electric-based ablation have been developed for focal tumors. In this book experts will deal with two main topics: I. What are the principles of the various ablation modalities, and II. How each method affects the tumor cells and their microenvironment, and how these effects are responsible for the induction of specific anti-tumor immunity. The aims of this book are thus: 1. Familiarize the readers with various methods of in situ tumor ablation. 2. Review the literature and stimulate comparisons on the efficacy of different ablation methods for the treatment of tumors of different histotypes. 3. Review the literature on the effects of various ablation methods on systemic and local anti tumor immunity and on other manifestations of the interactions of tumors with their microenvironment. 4. Stimulate comparative studies on the immunostimulatory effects of different ablation modalities.
650		0	_aMedicine.
650		0	_aCancer research.
650		0	_aImmunology.
650		0	_aRadiotherapy.
650		0	_aOncology.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aCancer Research.
650	2	4	_aOncology.
650	2	4	_aImmunology.
650	2	4	_aRadiotherapy.
700	1		_aKeisari, Yona. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400746930
830		0	_aThe Tumor Microenvironment ; _v5
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-4694-7
912			_aZDB-2-SBL
942			_2Dewey Decimal Classification _ceBooks
999			_c48415 _d48415