000 | 03234nam a22004337a 4500 | ||
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005 | 20160413122649.0 | ||
007 | cr nn 008mamaa | ||
008 | 121026s2013 ne | s |||| 0|eng d | ||
020 |
_a9789400752856 _9978-94-007-5285-6 |
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024 | 7 |
_a10.1007/978-94-007-5285-6 _2doi |
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050 | 4 | _aR-RZ | |
072 | 7 |
_aMBGR _2bicssc |
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072 | 7 |
_aMED000000 _2bisacsh |
|
082 | 0 | 4 |
_a610 _223 |
245 | 1 | 0 |
_aIdentification of Ligand Binding Site and Protein-Protein Interaction Area _h[electronic resource] / _cedited by Irena Roterman-Konieczna. |
264 | 1 |
_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013. |
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300 |
_aX, 170 p. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aFocus on Structural Biology, _x1571-4853 ; _v8 |
|
505 | 0 | _aContributors -- Foreword -- Chapter 1 SuMo, J-A. Chemelle, E. Bettler, CH. Combet, R. Terreux, CH. Geourjon, G. Deleage -- Chapter 2 Identification of pockets on protein surface to predict protein–ligand binding sites, Binding Huang -- Chapter 3 Can the structure of the hydrophobic core determine the complexation site?, M. Banach, L. Konieczny, I. Roterman -- Chapter 4 Comparative analysis of techniques oriented on the recognition of ligand binding area in proteins, P. Alejster, M. Banach, W. Jurkowski, D. Marchewka, I. Roterman -- Chapter 5 Docking predictions of protein-protein interactions and their assessment, Joel Janin -- Chapter 6 Prediction of protein-protein binding interfaces, D. Marchewka, W. Jurkowski, M. Banach, I. Roterman -- Chapter 7 Support for Cooperative Experiments in e-Science: From Scientific Workflows to Knowledge Sharing, A. Belloum, R. Cushing, S. Koulouzis, V. Korkhov, D. Vasunin, V. Guevara-Masis, Z. Zhao, M. Bubak -- Index. | |
520 | _aThis volume presents a review of the latest numerical techniques used to identify ligand binding and protein complexation sites. It should be noted that there are many other theoretical studies devoted to predicting the activity of specific proteins and that useful protein data can be found in numerous databases. The aim of advanced computational techniques is to identify the active sites in specific proteins and moreover to suggest a generalized mechanism by which such protein-ligand (or protein-protein) interactions can be effected. Developing such tools is not an easy task – it requires extensive expertise in the area of molecular biology as well as a firm grasp of numerical modeling methods. Thus, it is often viewed as a prime candidate for interdisciplinary research. | ||
650 | 0 | _aMedicine. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aBiomedicine general. |
700 | 1 |
_aRoterman-Konieczna, Irena. _eeditor. |
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710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9789400752849 |
830 | 0 |
_aFocus on Structural Biology, _x1571-4853 ; _v8 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-94-007-5285-6 |
912 | _aZDB-2-CMS | ||
942 |
_2Dewey Decimal Classification _ceBooks |
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999 |
_c48550 _d48550 |