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007 | cr nn 008mamaa | ||
008 | 130702s2013 ne | s |||| 0|eng d | ||
020 |
_a9789400768666 _9978-94-007-6866-6 |
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024 | 7 |
_a10.1007/978-94-007-6866-6 _2doi |
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050 | 4 | _aRC261-271 | |
072 | 7 |
_aMJCL _2bicssc |
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072 | 7 |
_aMED062000 _2bisacsh |
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082 | 0 | 4 |
_a614.5999 _223 |
245 | 1 | 0 |
_aEvolution-adjusted Tumor Pathophysiology: _h[electronic resource] : _bThe Novel Language of Tumor Biology / _cedited by Albrecht Reichle. |
264 | 1 |
_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013. |
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300 |
_aX, 453 p. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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505 | 0 | _aPreface.-I Introduction.-Communication ─ evolution ─ pathophysiology: An endogenous conjunction ─Instead of an introduction.-II Combined modularized therapies for metastatic tumors: Pointing to central problems of communication among ‘systems participators’ in tumors -- Applied systems biology for the control of metastatic cancer: Therapeutic top-down strategy for targeting the tumors’ normativity -- Targeting the proangiogenic network in angiosarcomas: Biomodulatory therapy.- Long-term results of combined modularized, immune-modulatory, angiostatic, and antiinflammatory therapy in systemically pre-treated multi-systems Langerhans cell histiocytosis.- Redirecting and modulating rationalizations of tumor-immanent normative functions in castration-resistant prostate ancer.-III Social engineering: Biomodulation, either endogenously initiated or by implementation of non-normative boundary conditions -- Non-hierarchically organized operations in malignancies: Stromal dysfunction induces hematopoetic malignancies.- Biomodulatory therapy approaches in renal clear cell carcinoma: A perspective.- Proteome analysis identified the PPARc ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.IV The tumors’ normativity: Reconstructing and operationalizing starting points for an evolution theory.- The philosophical quest of a cancer cell: Redefining existentialism.- The tumor’s normativity: Normative structures, action norms and decision maxims as therapeutic targets for tumor therapy.- Criticizable claims for the validity of communication acts in biological systems: Therapeutic implications in cancer.-V Evolution theory.- Evolution theory: Its practical relevance for understanding tumor development and specifying tumor therapy -- Modularity, subjectivity, intersubjectivity and normativity: Clinically applicable operative benchmarks -- Turning upside down the mode of science to emphasize and harness the impact of environmental communicative events. VI From genome- or organ-centric to rationalization-centric systematization of tumors -- Purposive-rational tumor therapy: Exploiting the tumor’s ‘living world’ for diversifying, specifying and personalizing tumor therapy -- Including rationalizations of tumor-associated normative notions in pathophysiologic considerations: Communication-theoretical implications.-VII Reconstruction of tumor-immanent normative functions, structures and decision maxims (hubs).- Bridging a diagnostic and therapeutic gap: Selecting, assessing and categorizing tumor-associated normative notions.- Personalizing tumor pathophysiology by diagnosing developmental problems in tumors with imaging techniques -- Biologic memory: Induction by metronomically administered combined modularized therapy.- VIII The tool of rationalizations constituting tumor-associated normative notions: The non-genomic counterpart of the tumor genome and therefore, an important therapeutic target for diversifying palliative care -- Diversifying and specifying palliative care for patients with metastatic cancer by therapeutic implementation of non-normative boundary conditions -- Targeting a hallmark of cancer: Simultaneous inflammation and tumor control for palliative care in metastatic cancer.-IX Novel clinical and pharmaceutical technology for bioengineering tumor response.- Combined modularized tumor therapy ─ tumor biology ─ and prognostic factors: Bioengineering tumor response.-X Objectifying the systems objects’ subjectivity in biological systems: A novel reification of the scientific picture about the ‘objective’ world -- The systems objects’ subjectivity as scientific object. Index. | |
520 | _aCombined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aCancer research. | |
650 | 0 | _aPharmaceutical technology. | |
650 | 0 | _aSystems biology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aCancer Research. |
650 | 2 | 4 | _aBiomedicine general. |
650 | 2 | 4 | _aSystems Biology. |
650 | 2 | 4 | _aPharmaceutical Sciences/Technology. |
700 | 1 |
_aReichle, Albrecht. _eeditor. |
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710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9789400768659 |
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-94-007-6866-6 |
912 | _aZDB-2-SBL | ||
942 |
_2Dewey Decimal Classification _ceBooks |
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999 |
_c48946 _d48946 |