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_a9783527633166 _q(electronic bk.) |
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_a10.1002/9783527633166 _bWiley InterScience _nhttp://www3.interscience.wiley.com |
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_aRM301.57 _b.P76 2011eb |
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_aQV 785 _bP962 2011 |
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082 | 0 | 4 |
_a615.191 _222 |
049 | _aMAIN | ||
245 | 0 | 0 |
_aProdrugs and Targeted Delivery : _bTowards Better ADME Properties. |
260 |
_aWeinheim : _bWiley-VCH, _c©2011. |
||
300 | _a1 online resource (522 pages). | ||
336 |
_atext _btxt _2rdacontent |
||
337 |
_acomputer _bc _2rdamedia |
||
338 |
_aonline resource _bcr _2rdacarrier |
||
490 | 1 |
_aMethods and Principles in Medicinal Chemistry ; _v[47] |
|
505 | 0 | _aFront Matter -- Prodrug Design and Intellectual Property. Prodrug Strategies in Drug Design / Jarkko Rautio -- The Molecular Design of Prodrugs by Functional Group / Victor R Guarino -- Intellectual Property Primer on Pharmaceutical Patents with a Special Emphasis on Prodrugs and Metabolites / Eyal H Barash -- Prodrugs Addressing ADMET Issues. Increasing Lipophilicity for Oral Drug Delivery / Majid Y Moridani -- Modulating Solubility Through Prodrugs for Oral and IV Drug Delivery / Victor R Guarino -- Prodrugs Designed to Target Transporters for Oral Drug Delivery / Mark S Warren, Jarkko Rautio -- Topical and Transdermal Delivery Using Prodrugs: Mechanism of Enhancement / Kenneth Sloan, Scott C Wasdo, Susruta Majumdar -- Ocular Delivery Using Prodrugs / Deep Kwatra, Ravi Vaishya, Ripal Gaudana, Jwala Jwala, Ashim K Mitra -- Reducing Presystemic Drug Metabolism / Majid Y Moridani -- Enzyme-Activated Prodrug Strategies for Site-Selective Drug Delivery / Krista Laine, Kristiina Huttunen -- Prodrug Approaches for Central Nervous System Delivery / Quentin R Smith, Paul R Lockman -- Directed Enzyme Prodrug Therapies / Dan Niculescu-Duvaz, Gabriel Negoita-Giras, Ion Niculescu-Duvaz, Douglas Hedley, Caroline J Springer -- Codrugs and Soft Drugs. Improving the Use of Drug Combinations Through the Codrug Approach / Peter A Crooks, Harpreet K Dhooper, Ujjwal Chakraborty -- Soft Drugs / Paul W Erhardt, Michael D Reese -- Preclinical and Clinical Consideration for Prodrugs. Pharmacokinetic and Biopharmaceutical Considerations in Prodrug Discovery and Development / John P O'Donnell -- The Impact of Pharmacogenetics on the Clinical Outcomes of Prodrugs / Jane P F Bai, Mike Pacanowski, Atiqur Rahman, Lawrence L Lesko -- Index. | |
505 | 0 | _aProdrugs and Targeted Delivery: Towards Better ADME Properties; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Prodrug Design and Intellectual Property; 1 Prodrug Strategies in Drug Design; 2 The Molecular Design of Prodrugs by Functional Group; 3 Intellectual Property Primer on Pharmaceutical Patents with a Special Emphasis on Prodrugs and Metabolites; Part Two: Prodrugs Addressing ADMET Issues; 4 Increasing Lipophilicity for Oral Drug Delivery; 5 Modulating Solubility Through Prodrugs for Oral and IV Drug Delivery. | |
505 | 8 | _a6 Prodrugs Designed to Target Transporters for Oral Drug Delivery7 Topical and Transdermal Delivery Using Prodrugs: Mechanism of Enhancement; 8 Ocular Delivery Using Prodrugs; 9 Reducing Presystemic Drug Metabolism; 10 Enzyme-Activated Prodrug Strategies for Site-Selective Drug Delivery; 11 Prodrug Approaches for Central Nervous System Delivery; 12 Directed Enzyme Prodrug Therapies; Part Three: Codrugs and Soft Drugs; 13 Improving the Use of Drug Combinations Through the Codrug Approach; 14 Soft Drugs; Part Four: Preclinical and Clinical Consideration for Prodrugs. | |
505 | 8 | _a15 Pharmacokinetic and Biopharmaceutical Considerations in Prodrug Discovery and Development16 The Impact of Pharmacogenetics on the Clinical Outcomes of Prodrugs; Index. | |
520 | _aThis topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development. | ||
588 | 0 | _aPrint version record. | |
504 | _aIncludes bibliographical references (pages 473-481) and index. | ||
650 | 0 | _aProdrugs. | |
650 | 0 | _aPharmacy. | |
650 | 0 | _aMedicine. | |
650 | 2 | 2 | _aProdrugs. |
650 | 2 | 2 | _aDrug Delivery Systems. |
650 | 7 |
_aMEDICAL _xDrug Guides. _2bisacsh |
|
650 | 7 |
_aMEDICAL _xPharmacology. _2bisacsh |
|
650 | 7 |
_aMEDICAL _xPharmacy. _2bisacsh |
|
650 | 7 |
_aMEDICAL _xNursing _xPharmacology. _2bisacsh |
|
650 | 7 |
_aMedicine. _2fast _0(OCoLC)fst01014893 |
|
650 | 7 |
_aPharmacy. _2fast _0(OCoLC)fst01060285 |
|
650 | 7 |
_aProdrugs. _2fast _0(OCoLC)fst01078135 |
|
655 | 4 | _aElectronic books. | |
700 | 1 | _aRautio, Jarkko. | |
700 | 1 |
_aMannhold, Raimund, _d1948- |
|
700 | 1 | _aKubinyi, Hugo. | |
710 | 2 | _aWiley InterScience (Online service) | |
776 | 0 | 8 |
_iPrint version: _aRautio, Jarkko. _tProdrugs and Targeted Delivery. _dWeinheim : Wiley-VCH, 2010 _z9783527633173 _w(OCoLC)700706105 |
830 | 0 | _aMethods and principles in medicinal chemistry. | |
856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9783527633166 _zWiley Online Library [Free Download only for SUST IP] |
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