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020 _a1118001044
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020 _a9781118001035
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020 _a1118001036
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037 _a10.1002/9781118001042
_bWiley InterScience
_nhttp://www3.interscience.wiley.com
050 4 _aRA1224.3
_b.B68 2011eb
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049 _aMAIN
245 0 0 _aApplications of toxicogenomics in safety evaluation and risk assessment /
_cedited by Darrell R. Boverhof, B. Bhaskar Gollapudi.
260 _aHoboken, N.J. :
_bJohn Wiley & Sons,
_c©2011.
300 _a1 online resource (xiii, 377 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _adata file
_2rda
380 _aBibliography
504 _aIncludes bibliographical references and index.
505 0 _aToxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan -- -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach.
520 _a"This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm"--Provided by publisher.
588 0 _aPrint version record.
650 0 _aGenetic toxicology.
650 0 _aToxicity testing.
650 0 _aHealth risk assessment.
650 7 _aHEALTH & FITNESS
_xDiseases
_xGenetic.
_2bisacsh
650 7 _aMEDICAL
_xGenetics.
_2bisacsh
650 7 _aGenetic toxicology.
_2fast
_0(OCoLC)fst00940097
650 7 _aHealth risk assessment.
_2fast
_0(OCoLC)fst00953250
650 7 _aToxicity testing.
_2fast
_0(OCoLC)fst01153336
650 2 _aToxicogenetics.
650 2 _aRisk Assessment.
655 4 _aElectronic books.
655 4 _aElectronic resource.
655 7 _aElectronic books.
_2local
700 1 _aBoverhof, Darrell R.
700 1 _aGollapudi, B. Bhaskar.
776 0 8 _iPrint version:
_tApplications of toxicogenomics in safety evaluation and risk assessment.
_dHoboken, N.J. : John Wiley & Sons, ©2011
_z9780470449820
_w(DLC) 2010043286
_w(OCoLC)671385938
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9781118001042
_zWiley Online Library [Free Download only for SUST IP]
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