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035 _a(OCoLC)779616898
_z(OCoLC)778622647
_z(OCoLC)781540190
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_z(OCoLC)824108355
_z(OCoLC)961501435
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037 _a10.1002/9783527644827
_bWiley InterScience
_nhttp://www3.interscience.wiley.com
050 4 _aRS431.P75
060 4 _aQU 55
072 7 _aMED
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082 0 4 _a615.3
_223
049 _aMAIN
245 0 0 _aTherapeutic proteins :
_bstrategies to modulate their plasma half-lives /
_cedited by Roland Kontermann.
264 1 _aWeinheim, Germany :
_bWiley-Blackwell, an imprint of John Wiley & Sons,
_c2012.
264 4 _c©2012
300 _a1 online resource (374 pages) :
_billustrations (some color)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _aGeneral information -- Half-life modulating strategies : an introduction -- Pharmacokinetics and half-life of protein therapeutics -- Half-life extension through chemical and post-translational modifications -- Half-life extension through PEGylation -- Half-life extension of therapeutic proteins via genetic fusion to recombinant PEG mimetics -- Half-life extension through O-glycosylation -- Polysialic acid and polysialylation to modulate antibody pharmacokinetics -- Half-life extension through HESylation -- Half-life modulation involving recycling by the neonatal Fc receptor -- The biology of the neonatal Fc receptor (FcRn) -- half-life extension by fusion to the Fc region -- Monomeric Fc fusion technology: an approach to create long-lasting clotting factors -- The diverse roles of FcRn: implications for antibody engineering -- Half-life extension by fusion to recombinant albumin -- AlbudAb technology platform: versatile albumin binding domains for the development of therapeutics with tunable half-lives -- Half-life extension by binding to albumin through an albumin binding domain -- Half-life extension by binding to albumin through small molecules -- Half-life extension with pharmaceutical formulations -- Half-life extension with pharmaceutical formulations: liposomes -- Half-life extension with pharmaceutical formulations: nanoparticles by the miniemulsion process.
588 0 _aOnline resource; title from resource home page (ebrary, viewed on June 17, 2014).
520 _aFor this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.
650 0 _aProtein drugs
_xDesign.
650 0 _aProteins
_xTherapeutic use.
650 2 _aProteins
_xpharmacokinetics.
650 2 _aHalf-Life.
650 7 _aMEDICAL
_xPharmacology.
_2bisacsh
650 7 _aProtein drugs
_xDesign.
_2fast
_0(OCoLC)fst01079680
650 7 _aProteins
_xTherapeutic use.
_2fast
_0(OCoLC)fst01079767
655 4 _aElectronic books.
700 1 _aKontermann, Roland,
_d1961-
_eeditor.
776 0 8 _iPrint version:
_tTherapeutic proteins.
_dWeinheim, Germany : Wiley-VCH, ©2011
_z9783527328499
_w(DLC) 2012540834
_w(OCoLC)768072878
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9783527644827
_zWiley Online Library [Free Download only for SUST IP]
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